To the Editor: Familial Mediterranean fever is an autosomalrecessive disorder characterized by acute attacks of fever andinflammation of serous tissues. The disease affects certainethnic groups, mainly Sephardic Jews, Armenians, Turks, andArabs.1 Renal amyloidosis is the most severe complication andleads inevitably to chronic renal failure. Turks have severedisease with a relatively high incidence of amyloidosis as comparedwith other ethnic groups.2,3
Recently, the international and the French familial Mediterraneanfever consortiums independently cloned the gene on the shortarm of chromosome 16 and identified four ancient missense mutationson chromosomes of familial Mediterranean fever carriers . . . [Full Text of this Article]
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