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Correspondence
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Volume 338:993-994 April 2, 1998 Number 14
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Familial Mediterranean Fever — Amyloidosis and the Val726Ala Mutation

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To the Editor: Familial Mediterranean fever is an autosomal recessive disorder characterized by acute attacks of fever and inflammation of serous tissues. The disease affects certain ethnic groups, mainly Sephardic Jews, Armenians, Turks, and Arabs.1 Renal amyloidosis is the most severe complication and leads inevitably to chronic renal failure. Turks have severe disease with a relatively high incidence of amyloidosis as compared with other ethnic groups.2,3

Recently, the international and the French familial Mediterranean fever consortiums independently cloned the gene on the short arm of chromosome 16 and identified four ancient missense mutations on chromosomes of familial Mediterranean fever carriers . . . [Full Text of this Article]

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