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Correction to Toh et al., N Engl J Med 337(20):1441-1448 November 13, 1997.

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Volume 338:995 April 2, 1998 Number 14
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Pernicious Anemia

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 by Toh, B.-H.
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 by Toh, B.-H.
To the Editor: The article by Toh et al. (Nov. 13 issue) 1 on pernicious anemia includes a discussion of the neurologic complications of this disorder. The authors ignore a major point, which is that the neurologic manifestations of vitamin B12 deficiency can occur in a patient with a normal hematocrit and normal red-cell indexes. This lack of parallelism between megaloblastic anemia and neurologic signs is an obstacle to the early diagnosis of neurologic disease due to vitamin B12 deficiency. This concept is supported by a series of 141 patients with neuropsychiatric disorders caused by cobalamin deficiency, of whom 40 (28 . . . [Full Text of this Article]

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