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Previous Volume 338:1162-1163 April 16, 1998 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Solovey et al. reported an increased number of activated circulating endothelial cells in patients with sickle cell anemia (Nov. 27 issue).¹ Although the mechanism that releases endothelial cells into the circulation is unclear, several points suggest that apoptosis may be responsible. An average of 34 percent of these circulating endothelial cells were dead, as assessed by nuclear staining with ethidium homodimer.¹ Dead cells stain with ethidium homodimer when the cell membrane is damaged and becomes permeable. A permeable cell membrane is a feature of necrotic cells and of the late stages of apoptosis, whereas in the early . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Stefanec, T. (1999). Circulating Apoptotic Endothelial Cells. Blood 94: 1482-1483 [Full Text]