For more than a century we have known that deep venous thrombosisor pulmonary embolism may be the presenting feature of an occultcancer. The association between venous thromboembolism and cancerraises three questions: What is the mechanism, how strong isthe association, and what are the implications for patient care?
The mechanisms of cancer-induced venous thrombosis have beenwidely studied, mainly in patients with overt cancers. Thesemechanisms include invasion of cancer cells into the vesselwall, compression of the vasculature by a tumor, and hypercoagulabilityinduced by the cancer. Studies of patients with solid tumorsor leukemia using . . . [Full Text of this Article]
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