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Previous Volume 338:1226-1227 April 23, 1998 Number 17 Next

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To the Editor: Physicians and pharmacists should be alert to a serious error that can occur in the preparation of replacement albumin solutions for plasmapheresis.

Plasmapheresis was performed in an elderly man who had myeloma with renal insufficiency. One plasma volume exchange was ordered, with 5 percent albumin as the replacement solution, with calcium, potassium, and magnesium supplements. Because of the lack of availability of 5 percent albumin, the hospital pharmacy used 25 percent albumin and diluted this solution 1:4 with sterile water to achieve a 5 percent solution. Reference was made to Trissel's Handbook on Injectable Drugs, the 1994 . . . [Full Text of this Article]

References

Related Letters:

More on Dangerous Dilution of 25 Percent Albumin
Kravath R. E., Trissel L. A., Manasse H. R ., Pierce L. R., Finlayson J. S., Epstein J. S.
Extract | Full Text  
N Engl J Med 1998; 339:634-635, Aug 27, 1998. Correspondence

This article has been cited by other articles:

• Kravath, R. E., Trissel, L. A., Manasse, H. R ., Pierce, L. R., Finlayson, J. S., Epstein, J. S. (1998). More on Dangerous Dilution of 25 Percent Albumin. NEJM 339: 634-635 [Full Text]