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Previous Volume 338:1303-1304 April 30, 1998 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Remodeling of the left ventricle by the process of hypertrophy is usually a response to increased afterload. This adaptive reaction maintains cardiac output. The most common pattern of hypertrophy is concentric remodeling due to systemic hypertension, in which there is replication of sarcomeres in parallel. Hypertrophy also results from genetic mutations involving the contractile apparatus, as in hypertrophic cardiomyopathy, which is unrelated to changes in afterload.

Echocardiography has made it possible to quantify hypertrophy and to describe the effects of hypertrophic cardiomyopathy on left ventricular architecture and function. These patterns have proved invaluable in identifying phenotypic expression in family pedigrees.¹ . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Van Driest, S. L., Ackerman, M. J., Ommen, S. R., Shakur, R., Will, M. L., Nishimura, R. A., Tajik, A. J., Gersh, B. J. (2002). Prevalence and Severity of "Benign" Mutations in the {beta}-Myosin Heavy Chain, Cardiac Troponin T, and {alpha}-Tropomyosin Genes in Hypertrophic Cardiomyopathy. Circulation 106: 3085-3090 [Abstract] [Full Text]  
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