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Correspondence
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Volume 338:129-131 January 8, 1998 Number 2
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Low-Molecular-Weight Heparin versus Unfractionated Heparin for Unstable Coronary Disease

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 by Cohen, M.
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To the Editor: The Efficacy and Safety of Subcutaneous Enoxaparin in Non–Q-Wave Coronary Events (ESSENCE) study (Aug. 14 issue),1 in which a low-molecular-weight heparin was found to be more effective than unfractionated heparin in reducing the incidence of ischemic events in patients with unstable angina or non–Q-wave myocardial infarction, prompted an editorial questioning the future role of unfractionated heparin in patients with acute coronary disease.2 In his editorial, Dr. Armstrong noted that although low-molecular-weight heparin was administered in a weight-adjusted dose, this was not the case with unfractionated heparin. Other differences in the use of the two heparin preparations included . . . [Full Text of this Article]

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