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Previous Volume 338:1592-1600 May 28, 1998 Number 22 Next

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A marked accumulation of eosinophils occurs in several important disorders, such as allergic diseases, parasitic infections, and cancer.¹ The level of eosinophils in the body is normally tightly regulated. In normal subjects, eosinophils account for only a small minority of peripheral-blood leukocytes, and their presence in tissues is primarily limited to the gastrointestinal mucosa.² In certain disease states, however, eosinophils can selectively accumulate in the peripheral blood or any tissue in the body. Any perturbation that results in eosinophilia, defined here as an abnormal accumulation of eosinophils in blood or tissue, can have profound clinical effects. Eosinophilia may be harmful, . . . [Full Text of this Article]

Clinical Aspects of Eosinophilia

Physiologic Features of Eosinophils

Proliferation

Adhesion and Migration

Chemoattraction

Survival and Destruction in Tissue

Pathogenesis of Eosinophilia in Clinical Disorders

Genetic Aspects of Atopy

Late-Phase Response

Regulation of Eosinophils by Th2 Lymphocytes and Mast Cells

Proinflammatory and Cytotoxic Effects

Drugs That Interfere with Eosinophilia or Eosinophil Products

Summary

Source Information

From the Department of Pediatrics, Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Ave., Cincinnati, OH 45229, where reprint requests should be addressed to Dr. Rothenberg.

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