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Previous Volume 338:1601-1607 May 28, 1998 Number 22 Next

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A number of common disorders of the peripheral nervous system, termed paraproteinemic neuropathies, are closely connected with the presence of excessive amounts of an abnormal immunoglobulin in the blood. These immunoglobulins can be detected by immunoelectrophoresis or the more sensitive immunofixation test. An estimated 10 percent of idiopathic polyneuropathies are of this type.^1,2,3 The anomalous blood proteins are usually monoclonal (termed M protein or M spike) and are the product of a single clone of plasma cells. They are clinically important because some of them have the properties of antibodies directed at components of the myelin or the axolemma. Others . . . [Full Text of this Article]

Glycoconjugates and the Immune Pathogenesis of Paraproteinemic Neuropathies

Monoclonal Gammopathy of Undetermined Significance

Multiple Myeloma

Waldenström's Macroglobulinemia

Osteosclerotic Myeloma, or the Poems Syndrome

Amyloid Neuropathy

Cryoglobulinemia

Neuropathy in Other Lymphoproliferative Disorders

Source Information

From the Neurology Service, St. Elizabeth's Medical Center, and Tufts University School of Medicine — both in Boston.

Address reprint requests to Dr. Gorson at the Division of Neurology, St. Elizabeth's Medical Center, 736 Cambridge St., Boston, MA 02135.

References

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