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Previous Volume 338:1626 May 28, 1998 Number 22 Next

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To the Editor: Reports of the association of allelic variants with common diseases will soon accelerate, driven by the twin engines of genomic sequencing and the discovery of polymorphisms. Three reports in the Journal — by Hershey et al. (Dec. 11 issue),¹ Iacoviello et al. (Jan. 8 issue),² and Kuivenhoven et al. (Jan 8 issue)³ — describe such associations, and accompanying editorials^4,5 examine issues of clinical utility and biologic plausibility. But before addressing these matters, we must first convince ourselves that putative associations are real. We raise two issues that should promote caution.

The first concerns population admixture, which can . . . [Full Text of this Article]

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