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Correspondence
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Volume 338:1771-1773 June 11, 1998 Number 24
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Hepatitis Associated with Hepatitis A Superinfection in Patients with Chronic Hepatitis C

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 by Vento, S.
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To the Editor: Vento et al. (Jan. 29 issue)1 reported 27 cases of acute hepatitis A among 595 patients with chronic liver disease who were positive for hepatitis B surface antigen (HBsAg) or hepatitis C virus (HCV). Of the 17 patients with acute viral hepatitis A and chronic HCV infection, fulminant liver failure developed in 7, and 6 of them died.

This surprisingly high fatality rate conflicts with data from the specific surveillance system of acute viral hepatitis (SEIEVA) established in Italy in 1985.2 Since 1993, approximately 50 percent of the Italian population, uniformly distributed throughout the country, has been . . . [Full Text of this Article]

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