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Previous Volume 338:1773-1774 June 11, 1998 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Barst, R. J. Related Article by McLaughlin, V. V. PubMed Citation

To the Editor: The study by McLaughlin et al. (Jan. 29 issue)¹ implies that hypertensive pulmonary arteries develop beneficial structural changes after prolonged treatment with prostacyclin in patients with primary pulmonary hypertension. Since marked remodeling occurs throughout the vascular tree by the time severe pulmonary hypertension develops, structural changes could occur either proximally or distally. One might conjecture that more recent (i.e., less fibrotic and therefore potentially more reversible) remodeling is located proximally rather than in the distal vessels.

One wonders whether the clinical benefits of prostacyclin may be due primarily to altered hemodynamics, with secondary effects on pulmonary-artery structure, . . . [Full Text of this Article]

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