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Previous Volume 338:1850-1851 June 18, 1998 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Parolini and coworkers (Jan. 29 issue)¹ describe an eight-year-old girl who had the Wiskott–Aldrich syndrome associated with a nonrandom pattern of inactivation of the maternally derived X chromosome. In the accompanying editorial, Puck and Willard² provide an elegant review of the mechanisms leading to a skewed pattern of X-chromosome inactivation in females. However, the reader may be left with the impression that unbalanced X-chromosome inactivation is a congenital feature, whether or not it is familial. We believe that the most prevalent form is indeed acquired and that this point has clinical relevance.

Recent studies by various laboratories . . . [Full Text of this Article]

References

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