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Case Records of the Massachusetts General Hospital
Weekly Clinicopathological Exercises
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Volume 338:1905-1913 June 25, 1998 Number 26
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Case 20-1998— A 53-Year-Old Man with Cardiac Amyloidosis and a Left Pulmonary Mass
John L. Berk, and Eugene J. Mark

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Presentation of Case

A 53-year-old man with cardiac amyloidosis was admitted to the hospital because of hemoptysis and a pulmonary lesion.

The patient had first been seen at this hospital four years earlier because of atrial fibrillation, congestive heart failure, and an embolic stroke. Microscopical examination of a specimen from a right ventricular endomyocardial biopsy showed amyloid believed to be related to transthyretin (prealbumin), a finding indicative of familial amyloidosis. A coronary angiographic study revealed minimal atherosclerosis. There was moderate global and inferior hypokinesis, with severe mitral regurgitation. Symptoms were well controlled with colchicine, furosemide, warfarin, and propranolol.

Twenty months before admission, the . . . [Full Text of this Article]

Differential Diagnosis

Clinical Diagnoses

Dr. John L. Berk's Diagnosis

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