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Previous Volume 338:1924 June 25, 1998 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Primary hyperoxaluria type I is an autosomal recessive disorder characterized by a deficiency of liver-specific peroxisomal alanine–glyoxylate aminotransferase (EC 2.6.1.44). The disease leads to increased urinary excretion of oxalate, causing urolithiasis, nephrocalcinosis, progressive renal insufficiency, and eventually, oxalosis — that is, the accumulation of insoluble oxalate throughout the body.

The interval between the onset of symptoms and the development of end-stage renal failure varies. Although optimal conservative therapy can delay end-stage renal failure, it usually cannot prevent it. Kidney transplantation to correct end-stage renal failure is frequently followed by recurrence of the disease in the transplanted kidney. . . . [Full Text of this Article]

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