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Editorial
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Volume 338:192-194 January 15, 1998 Number 3
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The Clinical Significance of Fusion Oncogenes in Cancer

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 by Kawai, A.
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The study of chromosomal translocations in tumors has revealed much about the molecular biology of cancer.1 The report by Kawai et al.2 in this issue of the Journal highlights an important question: how useful to patient care are discoveries in the molecular biology of cancer? It also poses the longer-term question of how realistic it is to attempt to use this information to design effective therapies. Chromosomal translocations have been particularly well studied in hematopoietic tumors, which can easily be prepared for detailed cytogenetic studies.1 Other types of tumors have also been studied, but with respect to solid tumors, consistent . . . [Full Text of this Article]

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