Papillary and Follicular Thyroid Carcinoma

doi:10.1056/NEJM199801293380506

Volume 338:297-306		January 29, 1998		Number 5

Papillary and Follicular Thyroid Carcinoma

Martin Jean Schlumberger, M.D.

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Papillary and follicular (differentiated) thyroid carcinomasare among the most curable cancers. However, some patients areat high risk for recurrent disease or even death. Most of thesepatients can be identified at the time of diagnosis by usingwell-established prognostic indicators. The extent of the initialtreatment and follow-up care should therefore be tailored tothe level of risk. Although treatment guidelines have been published,¹^,²clinical procedures vary considerably among clinicians.³

Epidemiology

Although thyroid nodules are common, differentiated thyroidcarcinomas are relatively rare. Clinically detectable thyroidcarcinomas constitute less than 1 percent of all human cancers.The annual incidence rate . . . [Full Text of this Article]

Pathogenesis

Oncogenes

Thyroid Irradiation

Other Factors

Pathological Features

Papillary Carcinoma

Follicular Carcinoma

Diagnosis

Prognostic Factors

Initial Treatment

Surgery

Iodine-131 Therapy

External Radiotherapy

Follow-Up

Thyroxine Treatment

Clinical and Ultrasonographic Examinations

Chest Radiography

Serum Thyroglobulin Measurements

Iodine-131 Total-Body Scanning

Local and Regional Recurrences

Distant Metastases

Diagnosis

Treatment

Complications of Treatment with Iodine-131

Acute Side Effects

Genetic Defects and Infertility

Carcinogenesis and Leukemogenesis

Conclusions

Source Information

From the University of Paris XI, Institut Gustave-Roussy, Rue Camille-Desmoulins, 94805 Villejuif CEDEX, France, where reprint requests should be addressed to Dr. Schlumberger.

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