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Previous Volume 338:333-334 January 29, 1998 Number 5 Next

Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor for Crohn's Disease

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: We question whether the study of monoclonal antibody cA2 to tumor necrosis factor , reported by Targan and colleagues (Oct. 9 issue),¹ specifically establishes the efficacy of the strategy of using antibody to tumor necrosis factor . The cA2 binds complement and has been reported to cause a profound monocytopenia in patients with rheumatoid arthritis,² an action that could itself be therapeutic in patients with Crohn's disease (though potentially hazardous) and that might explain why the results reported by Targan et al. were not dose-dependent. Did monocytopenia occur in the present study? If so, was there any . . . [Full Text of this Article]

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