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The specialty of critical care medicine is, in large part, devoted to the care and treatment of patients with sepsis and the consequences of systemic infection. Tissue hypoperfusion and organ-system derangements are the hallmarks of severe sepsis and also the main causes of morbidity and mortality in the disorder. One of the leaders in defining the clinical manifestations of sepsis was Roger C. Bone. He was instrumental in organizing the American College of Chest Physicians and Society of Critical Care Medicine Consensus Panel to develop working definitions of sepsis and multiorgan failure. Therefore, it is most appropriate that this textbook
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