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Previous Volume 338:479 February 12, 1998 Number 7 Next

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(Oxford Monographs on Medical Genetics. No. 33.) By Virginia P. Sybert. 675 pp., illustrated. New York, Oxford University Press, 1997. $195. ISBN 0-19-506218-3.

Dermatologists love to argue about disease taxonomy, and their efforts to define diseases over the past two centuries have relied primarily on phenotypes observable with the naked eye. That organ of detection can recognize distinctions that are more subtle than those recognized by means of the stethoscope, the x-ray, or the Petri dish — hence, the number of recognized skin diseases is enormous. Since so many of these abnormalities "run in families," it is not surprising that diseases of the skin have been a rich lode that has not escaped the recent attention of the molecular-genetics miners. It is thus . . . [Full Text of this Article]

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