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Previous Volume 338:548-550 February 19, 1998 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Recently, the pathologic process underlying nonsyndromic forms of inherited hearing impairment has been studied at the molecular level.¹ The previously localized DFNA3 and DFNB1 loci, which are associated with nonsyndromic deafness of dominant and recessive inheritance, have in white families been attributed to sense (M34T) and nonsense (W24X or W77X) mutations, respectively, of the gene encoding the gap-junction protein connexin 26 (Cx26 ).¹

We describe a different mutation of the Cx26 gene in several families in a village in eastern Ghana known nationwide for having an extraordinarily high prevalence of profound nonsyndromic hearing impairment.² A linkage . . . [Full Text of this Article]

References

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• Siemering, K., Manji, S. S.M., Hutchison, W. M., Du Sart, D., Phelan, D., Dahl, H.-H. M. (2006). Detection of Mutations in Genes Associated with Hearing Loss Using a Microarray-Based Approach. J. Mol. Diagn. 8: 483-489 [Abstract] [Full Text]  
• Gardner, P., Oitmaa, E., Messner, A., Hoefsloot, L., Metspalu, A., Schrijver, I. (2006). Simultaneous Multigene Mutation Detection in Patients With Sensorineural Hearing Loss Through a Novel Diagnostic Microarray: A New Approach for Newborn Screening Follow-up. Pediatrics 118: 985-994 [Abstract] [Full Text]  
• Luoma, P. T., Luo, N., Loscher, W. N., Farr, C. L., Horvath, R., Wanschitz, J., Kiechl, S., Kaguni, L. S., Suomalainen, A. (2005). Functional defects due to spacer-region mutations of human mitochondrial DNA polymerase in a family with an ataxia-myopathy syndrome. Hum Mol Genet 14: 1907-1920 [Abstract] [Full Text]