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Over the past two decades the field of bone biology has expanded rapidly and exponentially. This remarkable growth is due to a large extent to the development of tools that allow an understanding of the fundamental molecular and cellular mechanisms controlling bone metabolism in physiologic and pathophysiologic conditions. A spinoff of this research endeavor was the development of new diagnostic and therapeutic tools and their application to clinical investigations of various bone diseases. Moreover, skeletal disorders received progressively more attention with the appreciation of their prevalence in the population. One of these disorders, osteoporosis, was little known 20 years ago,
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