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Previous Volume 338:591 February 26, 1998 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Figure 1.

View larger version (62K): [in this window] [in a new window]   Figure 1. Platelet satellitism, an in vitro phenomenon of platelet rosetting around polymorphonuclear neutrophils, is observed exclusively in blood treated with EDTA as an anticoagulant at room temperature. Neither heparin nor citrate produces rosetting. The proposed mechanisms include immunologic bonding through EDTA-dependent antiplatelet and antineutrophil IgG autoantibodies directed against the glycoprotein IIb/IIIa complex and Fc receptors of platelets and neutrophils, respectively, and nonimmunologic adherence mediated by thrombospondin or the alpha-granule protein of other platelets. The results of both in vivo and in vitro platelet-function tests are normal. Phagocytosis of platelets by polymorphonuclear leukocytes and monocytes is sometimes seen. Severe . . . [Full Text of this Article]

 

Related Letters:

Platelet Satellitism
Peters M., Heyderman R. S., Klein N. J., Shahab N., Evans M. L.
Extract | Full Text  
N Engl J Med 1998; 339:131-132, Jul 9, 1998. Correspondence

This article has been cited by other articles:

• Peters, M., Heyderman, R. S., Klein, N. J., Shahab, N., Evans, M. L. (1998). Platelet Satellitism. NEJM 339: 131-132 [Full Text]