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Previous Volume 338:616-618 February 26, 1998 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Editorial by Schwartz, R. S. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Recently, two rare genetic disorders have been linked to abnormalities in a novel cytokine-signaling mechanism, and the growth of leukemia cells was shown to be inhibited by selective blockade of this mechanism.^1,2,3 The details of this signaling mechanism have emerged only within the past five years, yet it has already been the subject of more than 1000 scientific reports and promises to have many clinical applications. The discovery of this pathway was a serendipitous outcome of research on interferon.

Twenty years ago interferon was the avatar of the biotechnology revolution, but interest in this cytokine dimmed when its promise in . . . [Full Text of this Article]

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• Maier, J., Kincaid, C., Pagenstecher, A., Campbell, I. L. (2002). Regulation of Signal Transducer and Activator of Transcription and Suppressor of Cytokine-Signaling Gene Expression in the Brain of Mice with Astrocyte-Targeted Production of Interleukin-12 or Experimental Autoimmune Encephalomyelitis. Am. J. Pathol. 160: 271-288 [Abstract] [Full Text]  
• Price, G. E., Gaszewska-Mastarlarz, A., Moskophidis, D. (2000). The Role of Alpha/Beta and Gamma Interferons in Development of Immunity to Influenza A Virus in Mice. J. Virol. 74: 3996-4003 [Abstract] [Full Text]  
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• Schwartz, R. S. (1998). Polycythemia Vera -- Chance, Death, and Mutability. NEJM 338: 613-615 [Full Text]