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Correspondence
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Volume 338:619-620 February 26, 1998 Number 9
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Sustained-Release Bupropion for Smoking Cessation

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 by Hurt, R. D.
To the Editor: In their report on the results of a dose–response trial of sustained-release bupropion for smoking cessation, Hurt et al. (Oct. 23 issue)1 "recommend using the 300-mg dose (150 mg twice a day) as the target dose for most patients, given the favorable side-effect profile and the fact that there was less weight gain during the medication phase with this dose." We believe an initial dose of 150 mg a day may be more reasonable.

Safety is a concern because of dose-related risks of seizures (1 case per 1000), anaphylactoid reactions (1 to 3 cases per 1000), and . . . [Full Text of this Article]

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