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Correspondence
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Volume 338:622-623 February 26, 1998 Number 9
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Cytotoxic-T-Cell Responses in Early HIV-1 Infection

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by Musey, L.
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To the Editor: Musey et al. (Oct. 30 issue)1 suggest that their study shows that cytotoxic T lymphocytes have a modest effect of reducing the viral load, on the basis of the cross-sectional inverse correlation between human immunodeficiency virus type 1 (HIV-1) Env-specific cytotoxic T lymphocytes and plasma HIV RNA. This correlation may instead be due to the fact that the viral load is an inverse measure of the number of CD4+ lymphocytes, which help CD8+ cytotoxic T cells maintain responsiveness. This possibility could be investigated by adjusting for the CD4+ count when assessing the association between the cytotoxic-T-lymphocyte response . . . [Full Text of this Article]

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