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Volume 338:630 February 26, 1998 Number 9

Multiple Sclerosis: Clinical challenges and controversies

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Edited by Alan J. Thompson, Chris Polman, and Reinhard Hohlfeld. 360 pp., illustrated. London, Martin Dunitz, 1997. (Distributed by Mosby, St. Louis.) $99.50. ISBN 1-85317-428-9.

The incidence of multiple sclerosis is about 5 to 6 per 100,000 population, and despite the benefit of national support groups, patients are often devastated when the diagnosis is made. Equally, physicians caring for them feel helpless in the face of an illness for which there is no known cure or cause. Only in the past few years have definitive suppressant agents become available, but even these reduce the incidence of clinical relapses in remitting and relapsing multiple sclerosis by only about 30 percent, and their effect can be proved only in large controlled series. These agents are not without . . . [Full Text of this Article]




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