Acute Human Immunodeficiency Virus Type 1 Infection

doi:10.1056/NEJM199807023390107

Volume 339:33-39		July 2, 1998		Number 1

Acute Human Immunodeficiency Virus Type 1 Infection

James O. Kahn, M.D., and Bruce D. Walker, M.D.

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Acute human immunodeficiency virus type 1 (HIV-1) infectionis a transient symptomatic illness associated with high-titerHIV-1 replication and a robust and expansive immunologic responseto the invading pathogen. From 40 to 90 percent of new HIV-1infections are associated with symptomatic illness. This syndromeis often undiagnosed or misdiagnosed, since HIV-1 antibodiesare usually not detected during the early phase of infection.The diagnosis of acute HIV-1 infection requires a high indexof clinical suspicion and correct use of specific diagnosticlaboratory tests. Accurate early diagnosis is now particularlyimportant because of the potential clinical benefit of earlyantiretroviral . . . [Full Text of this Article]

Pathogenesis

Signs and Symptoms

Diagnosis

Treatment

Conclusions

Source Information

From the AIDS Program, San Francisco General Hospital and the University of California, San Francisco (J.O.K.), and Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Boston (B.D.W.).

Address reprint requests to Dr. Walker at the Partners AIDS Research Center, Massachusetts General Hospital, 149 13th St., Charlestown, MA 02129.

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