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Previous Volume 339:42-44 July 2, 1998 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The history of sickle cell disease shows how tortuous the road can be from the discovery of the mechanism of a disease to improvement in the care of affected patients. A series of extraordinary scientific achievements began in the 1940s: Pauling established sickle cell anemia as the first molecular disease, Ingram identified the critical amino acid substitution in the -globin chain, Perutz described the three-dimensional structure of hemoglobin, and Harris recognized the pathologic role of rigid intracellular polymers of hemoglobin S. Meanwhile, patients with sickle cell disease continued to suffer bouts of severe pain, disabling strokes, and fatal infections. Those . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Nietert, P. J., Abboud, M. R., Silverstein, M. D., Jackson, S. M. (2000). Bone marrow transplantation versus periodic prophylactic blood transfusion in sickle cell patients at high risk of ischemic stroke: a decision analysis. Blood 95: 3057-3064 [Abstract] [Full Text]  
• Xu, K., Shi, Z. M., Veeck, L. L., Hughes, M. R., Rosenwaks, Z. (1999). First Unaffected Pregnancy Using Preimplantation Genetic Diagnosis for Sickle Cell Anemia. JAMA 281: 1701-1706 [Abstract] [Full Text]  
• Sarnaik, S. A., Hsu, L., Files, B., Adams, R. J. (1998). Prevention of Stroke by Transfusions in Children with Sickle Cell Anemia. NEJM 339: 1477-1478 [Full Text]