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Previous Volume 339:687-688 September 3, 1998 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In patients with cystic fibrosis, the inability to maintain the luminal hydration of ducts that contain or secrete large molecules may affect multiple organs. The protein product of the gene that causes the disease — the cystic fibrosis transmembrane conductance regulator (CF TR) gene — functions as a cyclic AMP–regulated chloride channel.¹ The exocrine pancreas and, in males, the wolffian ducts are most susceptible to the disease and are affected earliest. In both cases, high concentrations of macromolecules can block the narrow, tortuous, and lengthy ducts. Nevertheless, the severity of the disease varies considerably. This heterogeneity must be . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Wyllie, R. (1999). Gastrointestinal Manifestations of Cystic Fibrosis. CLIN PEDIATR 38: 735-738  
• WHITCOMB, D C (1999). Hereditary pancreatitis: new insights into acute and chronic pancreatitis. Gut 45: 317-322 [Full Text]