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Previous Volume 339:702-703 September 3, 1998 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: X-linked adrenoleukodystrophy is an inherited recessive disorder characterized by a defect in peroxisomal -oxidation of very-long-chain fatty acids (those with more than 22 carbon atoms) and secondary neuroinflammatory damage.^1,2 Even though the accumulation of very-long-chain fatty acids in plasma and tissues occurs early, the neurologic manifestations are not observed until the age of 4 to 8 years for childhood adrenoleukodystrophy or 20 to 30 years for adrenomyeloneuropathy. The neurologic damage in X-linked adrenoleukodystrophy may be mediated by the activation of astrocytes and the induction of proinflammatory cytokines. At present, dietary restrictions and therapy with Lorenzo's oil are . . . [Full Text of this Article]

References

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• MOSER, H W (1999). Treatment of X-linked adrenoleukodystrophy with Lorenzo's oil. J. Neurol. Neurosurg. Psychiatry 67: 279-280 [Full Text]  
• van Geel, B M, Assies, J, Haverkort, E B, Koelman, J H T M, Verbeeten, B Jr, Wanders, R J A, Barth, P G (1999). Progression of abnormalities in adrenomyeloneuropathy and neurologically asymptomatic X-linked adrenoleukodystrophy despite treatment with "Lorenzo's oil". J. Neurol. Neurosurg. Psychiatry 67: 290-299 [Abstract] [Full Text]  
• Moser, H. W., Kemp, S., Smith, K. D. (1999). Mutational Analysis and the Pathogenesis of Variant X-linked Adrenoleukodystrophy Phenotypes. Arch Neurol 56: 273-275 [Full Text]