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Volume 339:704-705 September 3, 1998 Number 10
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Comparison of Beclomethasone, Salmeterol, and Placebo in Children with Asthma

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 by Simons, F. E. R.
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To the Editor: Simons et al. (Dec. 4 issue)1 report that inhaled beclomethasone is somewhat more effective than salmeterol in controlling symptoms of asthma in children and that beclomethasone retards children's growth, whereas salmeterol does not. Additional analyses of the data are needed to clarify the growth-impairing effects of beclomethasone.

Despite randomization at base line, the groups were not well balanced with respect to height. The mean height was 138.5 cm in the placebo group, 140.0 cm in the beclomethasone group, and 134.6 cm in the salmeterol group, and these differences were significant (P=0.04 for the overall comparison among groups . . . [Full Text of this Article]

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