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Previous Volume 339:746-754 September 10, 1998 Number 11 Next

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Although the cellular physiology of megakaryocyte and platelet production has been understood for nearly a decade, the humoral basis of this process has remained enigmatic until recently. "Thrombopoietin — At Last" heralded one editorial¹ when the cloning of the chief regulator of megakaryocyte and platelet production was reported.^2,3,4 The availability of the purified hormone has made possible new insights into many aspects of blood-cell development and provided a way to increase platelet production in patients with bone marrow failure. This review focuses on the physiology of thrombopoietin and megakaryocyte production, with a view to understanding how this information can affect . . . [Full Text of this Article]

Megakaryocyte Development

Cloning and Characterization of Thrombopoietin

Clinical Implications of the Regulation of Thrombopoietin Expression

Pharmacologic Properties of Thrombopoietin

Trials of Thrombopoietin

Preclinical Trials in States of Marrow Failure

Clinical Trials

Other Thrombopoietic Substances

Conclusions

Source Information

From the Division of Hematology, Box 357710, University of Washington, Seattle, WA 98195, where reprint requests should be addressed to Dr. Kaushansky.

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