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Correspondence
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Volume 339:776-777 September 10, 1998 Number 11
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Global Distribution of Transfusion-Transmitted Virus

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To the Editor: Transfusion-transmitted virus has recently been identified as a potential cause of post-transfusion non-A, non-B, non-C hepatitis.1 The virus has a single-stranded DNA genome whose organization is similar to those of members of the Parvoviridae.2 Transient viremia due to transfusion-transmitted virus was detected by the polymerase chain reaction (PCR) in three patients six to eight weeks after the transfusion of blood components and coincided with modest elevations of alanine aminotransferase. It has been proposed that transfusion-transmitted virus is the chloroform-resistant non-A, non-B agent shown to cause transient alanine aminotransferase elevations in chimpanzees.3

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