Doxorubicin (Adriamycin) has been used in oncologic practicesince the late 1960s. It held promise as a powerful drug inthe fight against cancer. The tumors most commonly respondingto doxorubicin when it is given as a single agent or in combinationwith other antitumor agents include breast and esophageal carcinomas;osteosarcoma, Kaposi's sarcoma, and soft-tissue sarcomas; andHodgkin's and non-Hodgkin's lymphomas. Other cancers that areless responsive to doxorubicin but that are still treated withthe drug because of its overall benefits include gastric, liver,bile-duct, pancreatic, and endometrial carcinomas. However,reports of fatal cardiotoxic effects of doxorubicin have . . . [Full Text of this Article]
Cause
Diagnosis
Physical Examination
Electrocardiography
Echocardiography and Angiocardiography
Endomyocardial Biopsy
Management
Prevention
Use of Analogues and "Cocktails"
Alternative Approaches to Drug Delivery
Cardioprotective Agents
Treatment
Future Prospects
Conclusions
Source Information
From the Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, and the Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Man., Canada.
Address reprint requests to Dr. Singal at the Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, 351 Tache Ave., Rm. R3022, Winnipeg, MB R2H 2A6, Canada.
References
Related Letters:
Doxorubicin-Induced Cardiomyopathy
Lipshultz S. E., Grenier M. A., Colan S. D., Ginsburg A. D., Swain S. M., Muggia F. M., Speyer J. L., Singal P. K., Olweny C. L.M., Li T.
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N Engl J Med 1999;
340:653-655, Feb 25, 1999.
Correspondence
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