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Editorial
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Volume 339:915-917 September 24, 1998 Number 13
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Death Rates from Coronary Disease — Progress and a Puzzling Paradox

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 by Rosamond, W. D.
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In the late 1940s, recognition of coronary heart disease (CHD) as the leading cause of death in the United States prompted efforts to identify factors promoting its occurrence, in the belief that the resultant insights would advance knowledge of the pathophysiology of atherosclerotic cardiovascular disease and pave the way for its prevention. Hypertension, hypercholesterolemia, and cigarette smoking were identified by the early 1960s as principal risk factors for CHD.1,2 More recently, clinical trials of antihypertensive drugs and lipid-lowering therapies, along with investigations of smoking cessation, have documented the benefits of treating these risk factors and established beyond any doubt their . . . [Full Text of this Article]

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Related Letters:

Rates of Death from Coronary Heart Disease
Gornel D. L., Gray D. P., Steele R., Sweeney K., Rosamond W. D., Chambless L. E., Folsom A. R., Levy D., Thom T. J.
Extract | Full Text  
N Engl J Med 1999; 340:730-732, Mar 4, 1999. Correspondence

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