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Correspondence
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Volume 339:922-923 September 24, 1998 Number 13
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Intranasal Influenzavirus Vaccine in Children

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 by Belshe, R. B.
To the Editor: The encouraging results of the study conducted by Belshe et al. (May 14 issue)1 of a live attenuated influenzavirus vaccine that can be administered intranasally to young children should be placed in context. In an earlier study, we randomly assigned 5210 normal, healthy subjects to receive either attenuated or inactivated influenzavirus vaccine or placebo.2 The study subjects, who were 1 to 65 years of age, received a total of 12,500 doses of vaccine over a five-year period. In contrast to the observation by Belshe et al. that the serologic response was poorer to the A/Texas/36/91-like (H1N1) component . . . [Full Text of this Article]

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