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Previous Volume 339:1005-1006 October 1, 1998 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In their article on the management of acid–base disorders, Adrogué and Madias (Jan. 1 issue)¹ omitted the role of THAM (tromethamine; tris-hydroxymethyl aminomethane) in the management of acidemia. A review of the subject was recently published.²

THAM is a biologically inert amino alcohol of low toxicity that buffers carbon dioxide and acids in vitro and in vivo. At 37°C, the pK_a (the negative logarithm of the acid ionization constant) of THAM is 7.8, making it a more effective buffer than sodium bicarbonate in the physiologic range of blood pH. THAM is a proton acceptor with a stoichiometric . . . [Full Text of this Article]

References

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• KALLET, R. H., JASMER, R. M., LUCE, J. M., LIN, L. H., MARKS, J. D. (2000). The Treatment of Acidosis in Acute Lung Injury with Tris-Hydroxymethyl Aminomethane (THAM). Am. J. Respir. Crit. Care Med. 161: 1149-1153 [Abstract] [Full Text]