A sentinel lymph node is the first lymph node to receive lymphaticdrainage from a tumor. It can be detected by injection of ablue dye or radioactive colloid around the primary tumor, whichtravels to and identifies the first draining (sentinel) node.Biopsy of a sentinel lymph node can reveal whether there arelymphatic metastases, thereby obviating the need for extensivedissection of the regional lymph-node basin. Sentinel-lymph-nodebiopsy has become a standard technique for determining the nodalstage of disease in patients with melanoma. Initial studiesof this method in patients with breast cancer suggest that sentinel-lymph-nodebiopsy . . . [Full Text of this Article]
Assessing the Accuracy of Sentinel-Lymph-Node Biopsy
Melanoma
Breast Cancer
The Importance of Axillary Nodal Staging
The Therapeutic Value of Axillary Lymph-Node Dissection
Sentinel-Lymph-Node Biopsy for Nodal Staging
Technical Issues
Summary
Address reprint requests to Dr. McMasters at the University of LouisvilleBrown Cancer Center, 529 S. Jackson St., Louisville, KY 40202.
References
Related Letters:
Sentinel-Lymph-Node Biopsy
Schillaci O., Scopinaro F., Abramson L. R., Retsas S., Krag D. N., Moffat F. L., Ashikaga T., McMasters K. M., Edwards M. J., Ross M. I.
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N Engl J Med 1999;
340:317-319, Jan 28, 1999.
Correspondence
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[Full Text]
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1998: 14-14
[Full Text]
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1998: 13-13
[Full Text]
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1998: 2-2
[Full Text]