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This year marks the 50th anniversary of the National Heart, Lung, and Blood Institute and of the American Heart Association. These organizations have contributed enormously to the research that has demystified atherosclerosis. We have moved from an era in which clinicians could only shrug their shoulders helplessly and wait for the infarction to an era in which we know with certainty that our interventions with respect to major risk factors hypercholesterolemia, hypertension, and cigarette smoking are saving lives. A book with the title Medical Management of Atherosclerosis would probably have been greeted with ridicule in 1948; in 1998,
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