Background In this study we tried to achieve successful transplantationin patients with acute leukemia with the use of hematopoieticstem cells from donors who shared only one HLA haplotype withthe recipient (a "full-haplotype mismatch"). To prevent graftfailure, large doses of T-cell–depleted hematopoieticstem cells were transplanted after a conditioning regimen ofenhanced myeloablation and immunosuppression was administeredto the recipient.
Methods Forty-three patients with high-risk acute leukemia whowere scheduled for transplantation received total-body irradiation,thiotepa, fludarabine, and antithymocyte globulin. The graftconsisted of peripheral-blood progenitor cells that had beenmobilized in the donor with recombinant granulocyte colony-stimulatingfactor and also, in 28 cases, bone marrow. Bone marrow fromthe donor was depleted of T lymphocytes by processing with soybeanagglutinin and E-rosetting. T-cell depletion of peripheral-bloodmononuclear cells was achieved by E-rosetting followed by positiveselection of CD34+ cells. No post-transplantation prophylaxisagainst graft-versus-host disease (GVHD) was administered.
Results In all the patients, full donor-type engraftment wasachieved. In none of the patients who could be evaluated didacute or chronic GVHD develop. Regimen-related toxicity wasminimal. Eleven of the 23 patients with acute lymphoblasticleukemia had a relapse, as did 2 of the 20 patients with acutemyeloid leukemia. Transplantation-related mortality was 40 percent.After a median follow-up of 18 months (range, 8 to 30), 12 ofthe 43 patients were alive and free of disease. All survivingpatients had a good quality of life.
Conclusions The main limitations of transplantation of bonemarrow from donors who are matched with the recipient for onlyone HLA haplotype — GVHD and graft failure — canbe overcome. Since most patients have a relative with one haplotypemismatch, advances in this method will increase the availabilityof hematopoietic-cell transplantation as curative therapy foracute leukemia.
Source Information
From the Hematopoietic Stem Cell Transplant Program, Department of Internal and Experimental Medicine (F.A., A. Tabilio, A.V., I.C., A. Terenzi, F.F., L.R., G.B., M.F.M.), and the Department of Radiotherapy (C.A., P.L.), University of Perugia, Perugia, Italy; and the Department of Immunology, Weizmann Institute, Rehovot, Israel (Y.R.). Other authors were Rita Felicini, M.D., Flavio Falcinelli, M.D., Alessandra Carotti, M.D., Katia Perruccio, M.D., Stelvio Ballanti, M.D., and Antonella Santucci, M.D. (Department of Internal and Experimental Medicine, University of Perugia), and Cesare Gambelunghe, M.D. (Blood Bank, Azienda Ospedaliera, Perugia).
Address reprint requests to Dr. Aversa at the Istituto di Ematologia, Università di Perugia, Policlinico Monteluce, Via Brunamonti, 06100 Perugia, Italy.
Hematopoietic Stem-Cell Transplantation for Acute Leukemia
Eiermann T. H., van Bekkum D. W., Vriesendorp H. M., Machida U., Kami M., Hirai H., Bolan C. D., Leitman S. F., Sasazuki T., Juji T., Kodera Y., Aversa F., Martelli M. F., Reisner Y.
Extract |
Full Text
N Engl J Med 1999;
340:809-812, Mar 11, 1999.
Correspondence
This article has been cited by other articles:
Porta, F., Locatelli, F., Burgio, G. R.
(2008). Hematopoietic stem cell transplantation: 40 years of continuous progress and evolution. haematol
93: 1607-1610
[Full Text]
Ciceri, F., Labopin, M., Aversa, F., Rowe, J. M., Bunjes, D., Lewalle, P., Nagler, A., Di Bartolomeo, P., Lacerda, J. F., Lupo Stanghellini, M. T., Polge, E., Frassoni, F., Martelli, M. F., Rocha, V., on behalf of the Acute Leukemia Working Party (ALW,
(2008). A survey of fully haploidentical hematopoietic stem cell transplantation in adults with high-risk acute leukemia: a risk factor analysis of outcomes for patients in remission at transplantation. Blood
112: 3574-3581
[Abstract][Full Text]
Vago, L., Forno, B., Sormani, M. P., Crocchiolo, R., Zino, E., Di Terlizzi, S., Lupo Stanghellini, M. T., Mazzi, B., Perna, S. K., Bondanza, A., Middleton, D., Palini, A., Bernardi, M., Bacchetta, R., Peccatori, J., Rossini, S., Roncarolo, M. G., Bordignon, C., Bonini, C., Ciceri, F., Fleischhauer, K.
(2008). Temporal, quantitative, and functional characteristics of single-KIR-positive alloreactive natural killer cell recovery account for impaired graft-versus-leukemia activity after haploidentical hematopoietic stem cell transplantation. Blood
112: 3488-3499
[Abstract][Full Text]
Stern, M., Ruggeri, L., Mancusi, A., Bernardo, M. E., de Angelis, C., Bucher, C., Locatelli, F., Aversa, F., Velardi, A.
(2008). Survival after T cell-depleted haploidentical stem cell transplantation is improved using the mother as donor. Blood
112: 2990-2995
[Abstract][Full Text]
Davies, J. K., Gribben, J. G., Brennan, L. L., Yuk, D., Nadler, L. M., Guinan, E. C.
(2008). Outcome of alloanergized haploidentical bone marrow transplantation after ex vivo costimulatory blockade: results of 2 phase 1 studies. Blood
112: 2232-2241
[Abstract][Full Text]
Zheng, H., Matte-Martone, C., Li, H., Anderson, B. E., Venketesan, S., Sheng Tan, H., Jain, D., McNiff, J., Shlomchik, W. D.
(2008). Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease. Blood
111: 2476-2484
[Abstract][Full Text]
Baumeister, S. H. C., Holig, K., Bornhauser, M., Meurer, M., Rieber, E. P., Schakel, K.
(2007). G-CSF mobilizes slanDCs (6-sulfo LacNAc+ dendritic cells) with a high proinflammatory capacity. Blood
110: 3078-3081
[Abstract][Full Text]
Ball, L. M., Bernardo, M. E., Roelofs, H., Lankester, A., Cometa, A., Egeler, R. M., Locatelli, F., Fibbe, W. E.
(2007). Cotransplantation of ex vivo expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation. Blood
110: 2764-2767
[Abstract][Full Text]
Ruggeri, L., Mancusi, A., Capanni, M., Urbani, E., Carotti, A., Aloisi, T., Stern, M., Pende, D., Perruccio, K., Burchielli, E., Topini, F., Bianchi, E., Aversa, F., Martelli, M. F., Velardi, A.
(2007). Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value.. Blood
110: 433-440
[Abstract][Full Text]
Ciceri, F., Bonini, C., Marktel, S., Zappone, E., Servida, P., Bernardi, M., Pescarollo, A., Bondanza, A., Peccatori, J., Rossini, S., Magnani, Z., Salomoni, M., Benati, C., Ponzoni, M., Callegaro, L., Corradini, P., Bregni, M., Traversari, C., Bordignon, C.
(2007). Antitumor effects of HSV-TK engineered donor lymphocytes after allogeneic stem-cell transplantation. Blood
109: 4698-4707
[Abstract][Full Text]
Rizzieri, D. A., Koh, L. P., Long, G. D., Gasparetto, C., Sullivan, K. M., Horwitz, M., Chute, J., Smith, C., Gong, J. Z., Lagoo, A., Niedzwiecki, D., Dowell, J. M., Waters-Pick, B., Liu, C., Marshall, D., Vredenburgh, J. J., Gockerman, J., Decastro, C., Moore, J., Chao, N. J.
(2007). Partially Matched, Nonmyeloablative Allogeneic Transplantation: Clinical Outcomes and Immune Reconstitution. JCO
25: 690-697
[Abstract][Full Text]
Sharon, N.
(2007). Lectins: Carbohydrate-specific Reagents and Biological Recognition Molecules. J. Biol. Chem.
282: 2753-2764
[Full Text]
Wehler, T. C., Nonn, M., Brandt, B., Britten, C. M., Grone, M., Todorova, M., Link, I., Khan, S. A., Meyer, R. G., Huber, C., Hartwig, U. F., Herr, W.
(2007). Targeting the activation-induced antigen CD137 can selectively deplete alloreactive T cells from antileukemic and antitumor donor T-cell lines. Blood
109: 365-373
[Abstract][Full Text]
Amrolia, P. J., Muccioli-Casadei, G., Huls, H., Adams, S., Durett, A., Gee, A., Yvon, E., Weiss, H., Cobbold, M., Gaspar, H. B., Rooney, C., Kuehnle, I., Ghetie, V., Schindler, J., Krance, R., Heslop, H. E., Veys, P., Vitetta, E., Brenner, M. K.
(2006). Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantation. Blood
108: 1797-1808
[Abstract][Full Text]
Copelan, E. A.
(2006). Hematopoietic stem-cell transplantation.. NEJM
354: 1813-1826
[Full Text]
Perruccio, K., Tosti, A., Burchielli, E., Topini, F., Ruggeri, L., Carotti, A., Capanni, M., Urbani, E., Mancusi, A., Aversa, F., Martelli, M. F., Romani, L., Velardi, A.
(2005). Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation. Blood
106: 4397-4406
[Abstract][Full Text]
Tallman, M. S., Gilliland, D. G., Rowe, J. M.
(2005). Drug therapy for acute myeloid leukemia. Blood
106: 1154-1163
[Abstract][Full Text]
Piccoli, C., Ria, R., Scrima, R., Cela, O., D'Aprile, A., Boffoli, D., Falzetti, F., Tabilio, A., Capitanio, N.
(2005). Characterization of Mitochondrial and Extra-mitochondrial Oxygen Consuming Reactions in Human Hematopoietic Stem Cells: NOVEL EVIDENCE OF THE OCCURRENCE OF NAD(P)H OXIDASE ACTIVITY. J. Biol. Chem.
280: 26467-26476
[Abstract][Full Text]
Dawson, M. A., Spencer, A.
(2005). Successful Use of Haploidentical Stem-Cell Transplantation With KIR Mismatch As Initial Therapy for Poor-Risk Myelodysplastic Syndrome. JCO
23: 4473-4474
[Full Text]
Aversa, F., Terenzi, A., Tabilio, A., Falzetti, F., Carotti, A., Ballanti, S., Felicini, R., Falcinelli, F., Velardi, A., Ruggeri, L., Aloisi, T., Saab, J. P., Santucci, A., Perruccio, K., Martelli, M. P., Mecucci, C., Reisner, Y., Martelli, M. F.
(2005). Full Haplotype-Mismatched Hematopoietic Stem-Cell Transplantation: A Phase II Study in Patients With Acute Leukemia at High Risk of Relapse. JCO
23: 3447-3454
[Abstract][Full Text]
Gur, H., Krauthgamer, R., Bachar-Lustig, E., Katchman, H., Arbel-Goren, R., Berrebi, A., Klein, T., Nagler, A., Tabilio, A., Martelli, M. F., Reisner, Y.
(2005). Immune regulatory activity of CD34+ progenitor cells: evidence for a deletion-based mechanism mediated by TNF-{alpha}. Blood
105: 2585-2593
[Abstract][Full Text]
Spitzer, T. R.
(2005). Haploidentical Stem Cell Transplantation: The Always Present but Overlooked Donor. ASH Education Book
2005: 390-395
[Abstract][Full Text]
Bellocchio, S., Moretti, S., Perruccio, K., Fallarino, F., Bozza, S., Montagnoli, C., Mosci, P., Lipford, G. B., Pitzurra, L., Romani, L.
(2004). TLRs Govern Neutrophil Activity in Aspergillosis. J. Immunol.
173: 7406-7415
[Abstract][Full Text]
Ichinohe, T., Uchiyama, T., Shimazaki, C., Matsuo, K., Tamaki, S., Hino, M., Watanabe, A., Hamaguchi, M., Adachi, S., Gondo, H., Uoshima, N., Yoshihara, T., Hatanaka, K., Fujii, H., Kawa, K., Kawanishi, K., Oka, K., Kimura, H., Itoh, M., Inukai, T., Maruya, E., Saji, H., Kodera, Y., for the Japanese Collaborative Study Group for NIM,
(2004). Feasibility of HLA-haploidentical hematopoietic stem cell transplantation between noninherited maternal antigen (NIMA)-mismatched family members linked with long-term fetomaternal microchimerism. Blood
104: 3821-3828
[Abstract][Full Text]
Lee, J., Sait, S. N., Wetzler, M.
(2004). Characterization of dendritic-like cells derived from t(9;22) acute lymphoblastic leukemia blasts. Int Immunol
16: 1377-1389
[Abstract][Full Text]
Flomenberg, N., Baxter-Lowe, L. A., Confer, D., Fernandez-Vina, M., Filipovich, A., Horowitz, M., Hurley, C., Kollman, C., Anasetti, C., Noreen, H., Begovich, A., Hildebrand, W., Petersdorf, E., Schmeckpeper, B., Setterholm, M., Trachtenberg, E., Williams, T., Yunis, E., Weisdorf, D.
(2004). Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood
104: 1923-1930
[Abstract][Full Text]
Zino, E., Frumento, G., Marktel, S., Sormani, M. P., Ficara, F., Terlizzi, S. D., Parodi, A. M., Sergeant, R., Martinetti, M., Bontadini, A., Bonifazi, F., Lisini, D., Mazzi, B., Rossini, S., Servida, P., Ciceri, F., Bonini, C., Lanino, E., Bandini, G., Locatelli, F., Apperley, J., Bacigalupo, A., Ferrara, G. B., Bordignon, C., Fleischhauer, K.
(2004). A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation. Blood
103: 1417-1424
[Abstract][Full Text]
Nagler, R.M., Nagler, A.
(2004). The Molecular Basis of Salivary Gland Involvement in Graft-vs.-Host Disease. J. Dent. Res.
83: 98-103
[Abstract][Full Text]
Kolb, H.-J., Schmid, C., Barrett, A. J., Schendel, D. J.
(2004). Graft-versus-leukemia reactions in allogeneic chimeras. Blood
103: 767-776
[Abstract][Full Text]
Gilroy, R. K., Coccia, P. F., Talmadge, J. E., Hatcher, L. I., Pirruccello, S. J., Shaw, B. W. Jr, Rubocki, R. J., Sudan, D. L., Langnas, A. N., Horslen, S. P.
(2004). Donor immune reconstitution after liver-small bowel transplantation for multiple intestinal atresia with immunodeficiency. Blood
103: 1171-1174
[Abstract][Full Text]
Caligiuri, M. A., Velardi, A., Scheinberg, D. A., Borrello, I. M.
(2004). Immunotherapeutic Approaches for Hematologic Malignancies. ASH Education Book
2004: 337-353
[Abstract][Full Text]
Michallet, M.-C., Saltel, F., Preville, X., Flacher, M., Revillard, J.-P., Genestier, L.
(2003). Cathepsin-B-dependent apoptosis triggered by antithymocyte globulins: a novel mechanism of T-cell depletion. Blood
102: 3719-3726
[Abstract][Full Text]
Bachar-Lustig, E., Reich-Zeliger, S., Reisner, Y.
(2003). Anti-third-party veto CTLs overcome rejection of hematopoietic allografts: synergism with rapamycin and BM cell dose. Blood
102: 1943-1950
[Abstract][Full Text]
Amrolia, P. J., Muccioli-Casadei, G., Yvon, E., Huls, H., Sili, U., Wieder, E. D., Bollard, C., Michalek, J., Ghetie, V., Heslop, H. E., Molldrem, J. J., Rooney, C. M., Schlinder, J., Vitetta, E., Brenner, M. K.
(2003). Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses. Blood
102: 2292-2299
[Abstract][Full Text]
Bornhauser, M., Storer, B., Slattery, J. T., Appelbaum, F. R., Deeg, H. J., Hansen, J., Martin, P. J., McDonald, G. B., Nichols, W. G., Radich, J., Woolfrey, A., Jenke, A., Schleyer, E., Thiede, C., Ehninger, G., Anasetti, C.
(2003). Conditioning with fludarabine and targeted busulfan for transplantation of allogeneic hematopoietic stem cells. Blood
102: 820-826
[Abstract][Full Text]
Grewal, S. S., Barker, J. N., Davies, S. M., Wagner, J. E.
(2003). Unrelated donor hematopoietic cell transplantation: marrow or umbilical cord blood?. Blood
101: 4233-4244
[Full Text]
Komatsu, M., Mammolenti, M., Jones, M., Jurecic, R., Sayers, T. J., Levy, R. B.
(2003). Antigen-primed CD8+ T cells can mediate resistance, preventing allogeneic marrow engraftment in the simultaneous absence of perforin-, CD95L-, TNFR1-, and TRAIL-dependent killing. Blood
101: 3991-3999
[Abstract][Full Text]
Shimazaki, C., Ochiai, N., Uchida, R., Okano, A., Fuchida, S.-i., Ashihara, E., Inaba, T., Fujita, N., Maruya, E., Nakagawa, M.
(2003). Non-T-cell-depleted HLA haploidentical stem cell transplantation in advanced hematologic malignancies based on the feto-maternal michrochimerism. Blood
101: 3334-3336
[Abstract][Full Text]
Marktel, S., Magnani, Z., Ciceri, F., Cazzaniga, S., Riddell, S. R., Traversari, C., Bordignon, C., Bonini, C.
(2003). Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell-depleted stem cell transplantation. Blood
101: 1290-1298
[Abstract][Full Text]
Amrolia, P. J., Reid, S. D., Gao, L., Schultheis, B., Dotti, G., Brenner, M. K., Melo, J. V., Goldman, J. M., Stauss, H. J.
(2003). Allorestricted cytotoxic T cells specific for human CD45 show potent antileukemic activity. Blood
101: 1007-1014
[Abstract][Full Text]
Davies, S. M., Ruggieri, L., DeFor, T., Wagner, J. E., Weisdorf, D. J., Miller, J. S., Velardi, A., Blazar, B. R.
(2002). Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Blood
100: 3825-3827
[Abstract][Full Text]
Gratwohl, A., Baldomero, H., Horisberger, B., Schmid, C., Passweg, J., Urbano-Ispizua, A.
(2002). Current trends in hematopoietic stem cell transplantation in Europe. Blood
100: 2374-2386
[Abstract][Full Text]
Sinha, M. L., Fry, T. J., Fowler, D. H., Miller, G., Mackall, C. L.
(2002). Interleukin 7 worsens graft-versus-host disease. Blood
100: 2642-2649
[Abstract][Full Text]
Guimond, M., Balassy, A., Barrette, M., Brochu, S., Perreault, C., Roy, D. C.
(2002). P-glycoprotein targeting: a unique strategy to selectively eliminate immunoreactive T cells. Blood
100: 375-382
[Abstract][Full Text]
Mutis, T., Blokland, E., Kester, M., Schrama, E., Goulmy, E.
(2002). Generation of minor histocompatibility antigen HA-1-specific cytotoxic T cells restricted by nonself HLA molecules: a potential strategy to treat relapsed leukemia after HLA-mismatched stem cell transplantation. Blood
100: 547-552
[Abstract][Full Text]
Min, D., Taylor, P. A., Panoskaltsis-Mortari, A., Chung, B., Danilenko, D. M., Farrell, C., Lacey, D. L., Blazar, B. R., Weinberg, K. I.
(2002). Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation. Blood
99: 4592-4600
[Abstract][Full Text]
Gur, H., Krauthgamer, R., Berrebi, A., Klein, T., Nagler, A., Tabilio, A., Martelli, M. F., Reisner, Y.
(2002). Tolerance induction by megadose hematopoietic progenitor cells: expansion of veto cells by short-term culture of purified human CD34+ cells. Blood
99: 4174-4181
[Abstract][Full Text]
Yang, Y.-G., Qi, J., Wang, M.-G., Sykes, M.
(2002). Donor-derived interferon gamma separates graft-versus-leukemia effects and graft-versus-host disease induced by donor CD8 T cells. Blood
99: 4207-4215
[Abstract][Full Text]
Schulz, A. S., Classen, C. F., Mihatsch, W. A., Sigl-Kraetzig, M., Wiesneth, M., Debatin, K.-M., Friedrich, W., Muller, S. M.
(2002). HLA-haploidentical blood progenitor cell transplantation in osteopetrosis. Blood
99: 3458-3460
[Abstract][Full Text]
Cooper, D. L., Petersdorf, E. W., Hansen, J. A., Anasetti, C.
(2002). HLA Matching for Hematopoietic Stem-Cell Transplants. NEJM
346: 1251-1252
[Full Text]
Ruggeri, L., Capanni, M., Urbani, E., Perruccio, K., Shlomchik, W. D., Tosti, A., Posati, S., Rogaia, D., Frassoni, F., Aversa, F., Martelli, M. F., Velardi, A.
(2002). Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants. Science
295: 2097-2100
[Abstract][Full Text]
Tzachanis, D., Berezovskaya, A., Nadler, L. M., Boussiotis, V. A.
(2002). Blockade of B7/CD28 in mixed lymphocyte reaction cultures results in the generation of alternatively activated macrophages, which suppress T-cell responses. Blood
99: 1465-1473
[Abstract][Full Text]
Drobyski, W. R., Klein, J., Flomenberg, N., Pietryga, D., Vesole, D. H., Margolis, D. A., Keever-Taylor, C. A.
(2002). Superior survival associated with transplantation of matched unrelated versus one-antigen-mismatched unrelated or highly human leukocyte antigen- disparate haploidentical family donor marrow grafts for the treatment of hematologic malignancies: establishing a treatment algorithm for recipients of alternative donor grafts. Blood
99: 806-814
[Abstract][Full Text]
Lipscomb, M. F., Masten, B. J.
(2002). Dendritic Cells: Immune Regulators in Health and Disease. Physiol. Rev.
82: 97-130
[Abstract][Full Text]
Hoelzer, D., Gokbuget, N., Ottmann, O., Pui, C.-H., Relling, M. V., Appelbaum, F. R., van Dongen, J. J.M., Szczepanski, T.
(2002). Acute Lymphoblastic Leukemia. ASH Education Book
2002: 162-192
[Abstract][Full Text]
Ho, V. T., Soiffer, R. J.
(2001). The history and future of T-cell depletion as graft-versus-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation. Blood
98: 3192-3204
[Full Text]
Georges, G. E., Storb, R., Bruno, B., Brodie, S. J., Thompson, J. D., Taranova, A. G., Zaucha, J. M., Little, M.-T., Zellmer, E., Moore, P. F., Gooley, T., Sale, G., Kiem, H.-P., Sandmaier, B. M., Lyons, R. M., Nash, R. A.
(2001). Engraftment of DLA-haploidentical marrow with ex vivo expanded, retrovirally transduced cytotoxic T lymphocytes. Blood
98: 3447-3455
[Abstract][Full Text]
Korbling, M., Anderlini, P.
(2001). Peripheral blood stem cell versus bone marrow allotransplantation: does the source of hematopoietic stem cells matter?. Blood
98: 2900-2908
[Abstract][Full Text]
Cohen, J. L., Boyer, O., Klatzmann, D.
(2001). Suicide gene therapy of graft-versus-host disease: immune reconstitution with transplanted mature T cells. Blood
98: 2071-2076
[Abstract][Full Text]
Gluckman, E.
(2001). Hematopoietic Stem-Cell Transplants Using Umbilical-Cord Blood. NEJM
344: 1860-1861
[Full Text]
Rocha, V., Cornish, J., Sievers, E. L., Filipovich, A., Locatelli, F., Peters, C., Remberger, M., Michel, G., Arcese, W., Dallorso, S., Tiedemann, K., Busca, A., Chan, K.-W., Kato, S., Ortega, J., Vowels, M., Zander, A., Souillet, G., Oakill, A., Woolfrey, A., Pay, A. L., Green, A., Garnier, F., Ionescu, I., Wernet, P., Sirchia, G., Rubinstein, P., Chevret, S., Gluckman, E.
(2001). Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia. Blood
97: 2962-2971
[Abstract][Full Text]
Volpi, I., Perruccio, K., Tosti, A., Capanni, M., Ruggeri, L., Posati, S., Aversa, F., Tabilio, A., Romani, L., Martelli, M. F., Velardi, A.
(2001). Postgrafting administration of granulocyte colony-stimulating factor impairs functional immune recovery in recipients of human leukocyte antigen haplotype-mismatched hematopoietic transplants. Blood
97: 2514-2521
[Abstract][Full Text]
Mencacci, A., Perruccio, K., Bacci, A., Cenci, E., Benedetti, R., Martelli, M. F., Bistoni, F., Coffman, R., Velardi, A., Romani, L.
(2001). Defective antifungal T-helper 1 (TH1) immunity in a murine model of allogeneic T-cell-depleted bone marrow transplantation and its restoration by treatment with TH2 cytokine antagonists. Blood
97: 1483-1490
[Abstract][Full Text]
Venditti, A., Buccisano, F., Del Poeta, G., Maurillo, L., Tamburini, A., Cox, C., Battaglia, A., Catalano, G., Del Moro, B., Cudillo, L., Postorino, M., Masi, M., Amadori, S.
(2000). Level of minimal residual disease after consolidation therapy predicts outcome in acute myeloid leukemia. Blood
96: 3948-3952
[Abstract][Full Text]
Cilloni, D., Carlo-Stella, C., Falzetti, F., Sammarelli, G., Regazzi, E., Colla, S., Rizzoli, V., Aversa, F., Martelli, M. F., Tabilio, A.
(2000). Limited engraftment capacity of bone marrow-derived mesenchymal cells following T-cell-depleted hematopoietic stem cell transplantation. Blood
96: 3637-3643
[Abstract][Full Text]
Leung, W., Hudson, M. M., Strickland, D. K., Phipps, S., Srivastava, D. K., Ribeiro, R. C., Rubnitz, J. E., Sandlund, J. T., Kun, L. E., Bowman, L. C., Razzouk, B. I., Mathew, P., Shearer, P., Evans, W. E., Pui, C.-H.
(2000). Late Effects of Treatment in Survivors of Childhood Acute Myeloid Leukemia. JCO
18: 3273-3279
[Abstract][Full Text]
Godder, K. T., Hazlett, L. J., Abhyankar, S. H., Chiang, K. Y., Christiansen, N. P., Bridges, K. D., Lee, C. G., Geier, S. S., Goon-Johnson, K. S., Gee, A. P., Pati, A. R., Parrish, R. S., Henslee-Downey, P. J.
(2000). Partially Mismatched Related-Donor Bone Marrow Transplantation for Pediatric Patients With Acute Leukemia: Younger Donors and Absence of Peripheral Blasts Improve Outcome. JCO
18: 1856-1866
[Abstract][Full Text]
Liu, Y.-J., Blom, B.
(2000). Introduction: TH2-inducing DC2 for immunotherapy. Blood
95: 2482-2483
[Full Text]
Arpinati, M., Green, C. L., Heimfeld, S., Heuser, J. E., Anasetti, C.
(2000). Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells. Blood
95: 2484-2490
[Abstract][Full Text]
McGlave, P. B., Shu, X. O., Wen, W., Anasetti, C., Nademanee, A., Champlin, R., Antin, J. H., Kernan, N. A., King, R., Weisdorf, D. J.
(2000). Unrelated donor marrow transplantation for chronic myelogenous leukemia: 9 years' experience of the National Marrow Donor Program. Blood
95: 2219-2225
[Abstract][Full Text]
Siena, S., Schiavo, R., Pedrazzoli, P., Carlo-Stella, C.
(2000). Therapeutic Relevance of CD34 Cell Dose in Blood Cell Transplantation for Cancer Therapy. JCO
18: 1360-1377
[Abstract][Full Text]
Vogel, W., Scheding, S., Kanz, L., Brugger, W.
(2000). Clinical Applications of CD34+ Peripheral Blood Progenitor Cells (PBPC). Stem Cells
18: 87-92
[Abstract][Full Text]
Burt, R. K.
(1999). Clinical Utility in Maximizing CD34+ Cell Count in Stem Cell Grafts. Stem Cells
17: 373-376
[Full Text]
Bachar-Lustig, E., Li, H. W., Gur, H., Krauthgamer, R., Marcus, H., Reisner, Y.
(1999). Induction of Donor-Type Chimerism and Transplantation Tolerance Across Major Histocompatibility Barriers in Sublethally Irradiated Mice by Sca-1+Lin- Bone Marrow Progenitor Cells: Synergism With Non-Alloreactive (Host x Donor)F1 T Cells. Blood
94: 3212-3221
[Abstract][Full Text]
Rondelli, D., Lemoli, R. M., Ratta, M., Fogli, M., Re, F., Curti, A., Arpinati, M., Tura, S.
(1999). Rapid Induction of CD40 on a Subset of Granulocyte Colony-Stimulating Factor-Mobilized CD34+ Blood Cells Identifies Myeloid Committed Progenitors and Permits Selection of Nonimmunogenic CD40- Progenitor Cells. Blood
94: 2293-2300
[Abstract][Full Text]
Ruggeri, L., Capanni, M., Casucci, M., Volpi, I., Tosti, A., Perruccio, K., Urbani, E., Negrin, R. S., Martelli, M. F., Velardi, A.
(1999). Role of Natural Killer Cell Alloreactivity in HLA-Mismatched Hematopoietic Stem Cell Transplantation. Blood
94: 333-339
[Abstract][Full Text]
Guinan, E. C., Boussiotis, V. A., Neuberg, D., Brennan, L. L., Hirano, N., Nadler, L. M., Gribben, J. G.
(1999). Transplantation of Anergic Histoincompatible Bone Marrow Allografts. NEJM
340: 1704-1714
[Abstract][Full Text]
Schwartz, R. S.
(1999). The New Immunology -- The End of Immunosuppressive Drug Therapy?. NEJM
340: 1754-1756
[Full Text]
Burt, R. K.
(1999). Clinical Utility in Maximizing CD34+ Cell Count in Stem Cell Grafts. The Oncologist
4: 265-268
[Full Text]
Eiermann, T. H., van Bekkum, D. W., Vriesendorp, H. M., Machida, U., Kami, M., Hirai, H., Bolan, C. D., Leitman, S. F., Sasazuki, T., Juji, T., Kodera, Y., Aversa, F., Martelli, M. F., Reisner, Y.
(1999). Hematopoietic Stem-Cell Transplantation for Acute Leukemia. NEJM
340: 809-812
[Full Text]
Parkman, R.
(1998). The Future of Placental-Blood Transplantation. NEJM
339: 1628-1629
[Full Text]
van Rood, J. J., Oudshoorn, M.
(1998). The Quest for a Bone Marrow Donor -- Optimal or Maximal HLA Matching?. NEJM
339: 1238-1239
[Full Text]
Previous
