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Correspondence
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Volume 339:1248-1249 October 22, 1998 Number 17
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A Mysterious Death

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 by Oldach, D. W.
To the Editor: Oldach et al. (June 11 issue)1 try to identify the disease that caused the death of Alexander the Great. They conclude that the diagnosis was "Salmonella typhi enteritis, complicated by bowel perforation and ascending paralysis."

The authors fail to mention what any physician who has treated patients with typhoid fever and most old textbooks2,3 and even more recent ones4 assert — namely, that perforation of the intestine in patients with typhoid fever occurs late in the course of the disease, most often during the 3rd week or the beginning of the 4th week (between the 15th . . . [Full Text of this Article]

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