FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 339:1349-1357 November 5, 1998 Number 19 Next

	Full Text PDF Letters Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background In patients with coronary heart disease and a broad range of cholesterol levels, cholesterol-lowering therapy reduces the risk of coronary events, but the effects on mortality from coronary heart disease and overall mortality have remained uncertain.

Methods In a double-blind, randomized trial, we compared the effects of pravastatin (40 mg daily) with those of a placebo over a mean follow-up period of 6.1 years in 9014 patients who were 31 to 75 years of age. The patients had a history of myocardial infarction or hospitalization for unstable angina and initial plasma total cholesterol levels of 155 to 271 mg per deciliter. Both groups received advice on following a cholesterol-lowering diet. The primary study outcome was mortality from coronary heart disease.

Results Death from coronary heart disease occurred in 8.3 percent of the patients in the placebo group and 6.4 percent of those in the pravastatin group, a relative reduction in risk of 24 percent (95 percent confidence interval, 12 to 35 percent; P< 0.001). Overall mortality was 14.1 percent in the placebo group and 11.0 percent in the pravastatin group (relative reduction in risk, 22 percent; 95 percent confidence interval, 13 to 31 percent; P<0.001). The incidence of all cardiovascular outcomes was consistently lower among patients assigned to receive pravastatin; these outcomes included myocardial infarction (reduction in risk, 29 percent; P<0.001), death from coronary heart disease or nonfatal myocardial infarction (a 24 percent reduction in risk, P<0.001), stroke (a 19 percent reduction in risk, P=0.048), and coronary revascularization (a 20 percent reduction in risk, P<0.001). The effects of treatment were similar for all predefined subgroups. There were no clinically significant adverse effects of treatment with pravastatin.

Conclusions Pravastatin therapy reduced mortality from coronary heart disease and overall mortality, as compared with the rates in the placebo group, as well as the incidence of all prespecified cardiovascular events in patients with a history of myocardial infarction or unstable angina who had a broad range of initial cholesterol levels.

Source Information

Address reprint requests to the National Health and Medical Research Council Clinical Trials Centre, Mallett St. Campus, University of Sydney, NSW 2006, Australia. Drs. Andrew Tonkin and R. John Simes assume responsibility for the overall content of the manuscript.

Full Text of this Article

Related Letters:

Pravastatin and Coronary Heart Disease
Meyer F. P., Bloom J. M., Tonkin A., Hunt D., Simes R. J., The LIPID Study Group
Extract | Full Text  
N Engl J Med 1999; 340:1115-1117, Apr 8, 1999. Correspondence

Unstable Angina Pectoris
Colwell N. S., Buckley B. M., Murphy M. B., Shavelle D. M., Wuthrich D. A., Srivathsan K., Showalter J. C., Dieter R. S., Yeghiazarians Y., Stone P. H.
Extract | Full Text  
N Engl J Med 2000; 342:1676-1678, Jun 1, 2000. Correspondence

This article has been cited by other articles:

• Rosenzweig, J. L., Ferrannini, E., Grundy, S. M., Haffner, S. M., Heine, R. J., Horton, E. S., Kawamori, R. (2008). Primary Prevention of Cardiovascular Disease and Type 2 Diabetes in Patients at Metabolic Risk: An Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab. 93: 3671-3689 [Abstract] [Full Text]  
• Alsheikh-Ali, A. A., Trikalinos, T. A., Kent, D. M., Karas, R. H. (2008). Statins, Low-Density Lipoprotein Cholesterol, and Risk of Cancer. J Am Coll Cardiol 52: 1141-1147 [Abstract] [Full Text]  
• Nichol, G., Thomas, E., Callaway, C. W., Hedges, J., Powell, J. L., Aufderheide, T. P., Rea, T., Lowe, R., Brown, T., Dreyer, J., Davis, D., Idris, A., Stiell, I. (2008). Regional Variation in Out-of-Hospital Cardiac Arrest Incidence and Outcome. JAMA 300: 1423-1431 [Abstract] [Full Text]  
• Cayley, W. E. (2008). Monitoring Cholesterol Levels: Understanding Variance and Finding the Most Useful Data. ANN INTERN MED 149: 436-437 [Full Text]  
• Giraldez, R. R., Giugliano, R. P., Mohanavelu, S., Murphy, S. A., McCabe, C. H., Cannon, C. P., Braunwald, E. (2008). Baseline Low-Density Lipoprotein Cholesterol Is an Important Predictor of the Benefit of Intensive Lipid-Lowering Therapy: A PROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22) Analysis. J Am Coll Cardiol 52: 914-920 [Abstract] [Full Text]  
• Bruschke, A. V.G., Jukema, J. W. (2008). Aggressive Therapy Is Not Always the Best Therapy. J Am Coll Cardiol 52: 921-923 [Full Text]  
• Steg, P. G., Kerner, A., Van de Werf, F., Lopez-Sendon, J., Gore, J. M., FitzGerald, G., Feldman, L. J., Anderson, F. A., Avezum, A., for the Global Registry of Acute Coronary Events (, (2008). Impact of In-Hospital Revascularization on Survival in Patients With Non-ST-Elevation Acute Coronary Syndrome and Congestive Heart Failure. Circulation 118: 1163-1171 [Abstract] [Full Text]  
• Wei, L, Lang, C C, Sullivan, F M, Boyle, P, Wang, J, Pringle, S D, MacDonald, T M (2008). Impact on mortality following first acute myocardial infarction of distance between home and hospital: cohort study. Heart 94: 1141-1146 [Abstract] [Full Text]  
• Goldstein, L. B., Amarenco, P., LaMonte, M., Gilbert, S., Messig, M., Callahan, A., Hennerici, M., Sillesen, H., Welch, K. M. A., on behalf of the SPARCL Investigators, (2008). Relative Effects of Statin Therapy on Stroke and Cardiovascular Events in Men and Women: Secondary Analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study. Stroke 39: 2444-2448 [Abstract] [Full Text]  
• Bhindi, R., Ormerod, O., Newton, J., Banning, A.P., Testa, L. (2008). Interaction between statins and clopidogrel: is there anything clinically relevant?. QJM 0: hcn089v1-hcn089 [Abstract] [Full Text]  
• Fonseca, V. A., Rosenstock, J., Wang, A. C., Truitt, K. E., Jones, M. R. (2008). Colesevelam HCl Improves Glycemic Control and Reduces LDL Cholesterol in Patients With Inadequately Controlled Type 2 Diabetes on Sulfonylurea-Based Therapy. Diabetes Care 31: 1479-1484 [Abstract] [Full Text]  
• Kataoka, H. (2008). Response to Letter by Paraskevas. Stroke 39: e135-e135 [Full Text]  
• Filippatos, T. D., Mikhailidis, D. P. (2008). Statins and Heart Failure. ANGIOLOGY 59: 58S-61S [Abstract]  
• Woodard, J., Sassano, A., Hay, N., Platanias, L. C. (2008). Statin-Dependent Suppression of the Akt/Mammalian Target of Rapamycin Signaling Cascade and Programmed Cell Death 4 Up-Regulation in Renal Cell Carcinoma. Clin. Cancer Res. 14: 4640-4649 [Abstract] [Full Text]  
• Zhou, M.-S., Schuman, I. H., Jaimes, E. A., Raij, L. (2008). Renoprotection by statins is linked to a decrease in renal oxidative stress, TGF-{beta}, and fibronectin with concomitant increase in nitric oxide bioavailability. Am. J. Physiol. Renal Physiol. 295: F53-F59 [Abstract] [Full Text]  
• Reaume, K. T, Erickson, S. R, Dorsch, M. P, Dunham, N. L., Hiniker, S. M, Prabhakar, N., Kline-Rogers, E. M, Eagle, K. A (2008). Effects of Cerivastatin Withdrawal on Statin Persistence. The Annals of Pharmacotherapy 42: 956-961 [Abstract] [Full Text]  
• Tanaka, K., Ishikawa, Y., Yokoyama, M., Origasa, H., Matsuzaki, M., Saito, Y., Matsuzawa, Y., Sasaki, J., Oikawa, S., Hishida, H., Itakura, H., Kita, T., Kitabatake, A., Nakaya, N., Sakata, T., Shimada, K., Shirato, K., for the JELIS Investigators, Japan, (2008). Reduction in the Recurrence of Stroke by Eicosapentaenoic Acid for Hypercholesterolemic Patients: Subanalysis of the JELIS Trial. Stroke 39: 2052-2058 [Abstract] [Full Text]  
• U.S. Preventive Services Task Force, (2008). Screening for Type 2 Diabetes Mellitus in Adults: U.S. Preventive Services Task Force Recommendation Statement. ANN INTERN MED 148: 846-854 [Abstract] [Full Text]  
• Glasziou, P. P., Irwig, L., Heritier, S., Simes, R. J., Tonkin, A., for the LIPID Study Investigators, (2008). Monitoring Cholesterol Levels: Measurement Error or True Change?. ANN INTERN MED 148: 656-661 [Abstract] [Full Text]  
• Caymaz, H. O., Yuksel, G. (2008). Fate of Incidental, Asymptomatic Lesions Discovered During Percutaneous Coronary Intervention. ANGIOLOGY 59: 193-197 [Abstract]  
• Brunzell, J. D., Davidson, M., Furberg, C. D., Goldberg, R. B., Howard, B. V., Stein, J. H., Witztum, J. L. (2008). Lipoprotein Management in Patients With Cardiometabolic Risk: Consensus Conference Report From the American Diabetes Association and the American College of Cardiology Foundation. J Am Coll Cardiol 51: 1512-1524 [Full Text]  
• Betteridge, D. J., DeFronzo, R. A., Chilton, R. J. (2008). PROactive: time for a critical appraisal. Eur Heart J 29: 969-983 [Abstract] [Full Text]  
• Nusca, A., Melfi, R., Di Sciascio, G. (2008). Review: Percutaneous coronary interventions and statins therapy. Therapeutic Advances in Cardiovascular Disease 2: 101-107 [Abstract]  
• West, M. J., Nestel, P. J., Kirby, A. C., Schnabel, R., Sullivan, D., Simes, R. J., Pollicino, C., Lubos, E., Munzel, T. F., White, H. D., Tonkin, A. M., Bickel, C., Tiret, L., Blankenberg, S., for the LIPID Study Investigators, (2008). The value of N-terminal fragment of brain natriuretic peptide and tissue inhibitor of metalloproteinase-1 levels as predictors of cardiovascular outcome in the LIPID study. Eur Heart J 29: 923-931 [Abstract] [Full Text]  
• MacFadyen, R. J., Ng Kam Chuen, M. J. (2008). Developing the utility of blood biomarker associations beyond population sample linkage to events in cardiovascular patients. Eur Heart J 29: 837-839 [Full Text]  
• Brunzell, J. D., Davidson, M., Furberg, C. D., Goldberg, R. B., Howard, B. V., Stein, J. H., Witztum, J. L. (2008). Lipoprotein Management in Patients With Cardiometabolic Risk: Consensus statement from the American Diabetes Association and the American College of Cardiology Foundation. Diabetes Care 31: 811-822 [Full Text]  
• Griel, A. E., Cao, Y., Bagshaw, D. D., Cifelli, A. M., Holub, B., Kris-Etherton, P. M. (2008). A Macadamia Nut-Rich Diet Reduces Total and LDL-Cholesterol in Mildly Hypercholesterolemic Men and Women. J. Nutr. 138: 761-767 [Abstract] [Full Text]  
• Wenger, N K, Lewis, S J, Welty, F K, Herrington, D M, Bittner, V, on behalf of the TNT Steering Committee and Invest, (2008). Beneficial effects of aggressive low-density lipoprotein cholesterol lowering in women with stable coronary heart disease in the Treating to New Targets (TNT) study. Heart 94: 434-439 [Abstract] [Full Text]  
• Athyros, V. G., Kakafika, A. I., Tziomalos, K., Karagiannis, A., Mikhailidis, D. P. (2008). CORONA, Statins, and Heart Failure: Who Lost the Crown?. ANGIOLOGY 59: 5-8  
• Badger, S. A., Soong, C. V., Lee, B., Swain, G. R., McGuigan, K. E. (2008). Prescribing Practice of General Practitioners in Northern Ireland for Peripheral Arterial Disease. ANGIOLOGY 59: 57-63 [Abstract]  
• Nassief, A., Marsh, J. D. (2008). Statin Therapy for Stroke Prevention. Stroke 39: 1042-1048 [Abstract] [Full Text]  
• Bell, K. J L, Irwig, L., Craig, J. C, Macaskill, P. (2008). Use of randomised trials to decide when to monitor response to new treatment. BMJ 336: 361-365 [Full Text]  
• Vergouwen, M. D.I., de Haan, R. J., Vermeulen, M., Roos, Y. B.W.E.M. (2008). Statin Treatment and the Occurrence of Hemorrhagic Stroke in Patients With a History of Cerebrovascular Disease. Stroke 39: 497-502 [Abstract] [Full Text]  
• Wienbergen, H., Senges, J., Gitt, A. K. (2008). Should We Prescribe Statin and Aspirin for Every Diabetic Patient?: Is it time for a polypill?. Diabetes Care 31: S222-S225 [Full Text]  
• Superko, H. R., King, S. III (2008). Lipid Management to Reduce Cardiovascular Risk: A New Strategy Is Required. Circulation 117: 560-568 [Full Text]  
• Mizuno, K., Nakaya, N., Ohashi, Y., Tajima, N., Kushiro, T., Teramoto, T., Uchiyama, S., Nakamura, H., for the MEGA Study Group, (2008). Usefulness of Pravastatin in Primary Prevention of Cardiovascular Events in Women: Analysis of the Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese (MEGA Study). Circulation 117: 494-502 [Abstract] [Full Text]  
• Afilalo, J., Duque, G., Steele, R., Jukema, J. W., de Craen, A. J.M., Eisenberg, M. J. (2008). Statins for secondary prevention in elderly patients: a hierarchical bayesian meta-analysis.. J Am Coll Cardiol 51: 37-45 [Abstract] [Full Text]  
• McWilliams, J. M., Meara, E., Zaslavsky, A. M., Ayanian, J. Z. (2007). Health of Previously Uninsured Adults After Acquiring Medicare Coverage. JAMA 298: 2886-2894 [Abstract] [Full Text]  
• Natarajan, N., Putnam, R. W., Yip, A. M., Frail, D. (2007). Family practice patients' adherence to statin medications. cfp 53: 2144-2145 [Abstract] [Full Text]  
• Holman, J. R. (2007). Some Docs in Denial About Statin Side Effects. DOC News 4: 1-12 [Full Text]  
• Rosengarten, B., Auch, D., Kaps, M. (2007). Effects of Initiation and Acute Withdrawal of Statins on the Neurovascular Coupling Mechanism in Healthy, Normocholesterolemic Humans. Stroke 38: 3193-3197 [Abstract] [Full Text]  
• Henyan, N. N, Riche, D. M, East, H. E, Gann, P. N (2007). Impact of Statins on Risk of Stroke: A Meta-Analysis. The Annals of Pharmacotherapy 41: 1937-1945 [Abstract] [Full Text]  
• Kjekshus, J., Apetrei, E., Barrios, V., Bohm, M., Cleland, J. G.F., Cornel, J. H., Dunselman, P., Fonseca, C., Goudev, A., Grande, P., Gullestad, L., Hjalmarson, A., Hradec, J., Janosi, A., Kamensky, G., Komajda, M., Korewicki, J., Kuusi, T., Mach, F., Mareev, V., McMurray, J. J.V., Ranjith, N., Schaufelberger, M., Vanhaecke, J., van Veldhuisen, D. J., Waagstein, F., Wedel, H., Wikstrand, J., the CORONA Group, (2007). Rosuvastatin in Older Patients with Systolic Heart Failure. NEJM 357: 2248-2261 [Abstract] [Full Text]  
• Grover, S. A., Lowensteyn, I., Joseph, L., Kaouache, M., Marchand, S., Coupal, L., Boudreau, G., for the Cardiovascular Health Evaluation to Improv, (2007). Patient Knowledge of Coronary Risk Profile Improves the Effectiveness of Dyslipidemia Therapy: The CHECK-UP Study: A Randomized Controlled Trial. Arch Intern Med 167: 2296-2303 [Abstract] [Full Text]  
• Arsenault, B. J., Lemieux, I., Despres, J.-P., Wareham, N. J., Luben, R., Kastelein, J. J.P., Khaw, K.-T., Boekholdt, S. M. (2007). Cholesterol levels in small LDL particles predict the risk of coronary heart disease in the EPIC-Norfolk prospective population study. Eur Heart J 28: 2770-2777 [Abstract] [Full Text]  
• Feringa, H. H.H., Schouten, O., Karagiannis, S. E., Brugts, J., Elhendy, A., Boersma, E., Vidakovic, R., van Sambeek, M. R.H.M., Noordzij, P. G., Bax, J. J., Poldermans, D. (2007). Intensity of Statin Therapy in Relation to Myocardial Ischemia, Troponin T Release, and Clinical Cardiac Outcome in Patients Undergoing Major Vascular Surgery. J Am Coll Cardiol 50: 1649-1656 [Abstract] [Full Text]  
• Ford, I., Murray, H., Packard, C. J., Shepherd, J., Macfarlane, P. W., Cobbe, S. M., the West of Scotland Coronary Prevention Study Gro, (2007). Long-Term Follow-up of the West of Scotland Coronary Prevention Study. NEJM 357: 1477-1486 [Abstract] [Full Text]  
• Authors/Task Force Members, , Graham, I., Atar, D., Borch-Johnsen, K., Boysen, G., Burell, G., Cifkova, R., Dallongeville, J., De Backer, G., Ebrahim, S., Gjelsvik, B., Herrmann-Lingen, C., Hoes, A., Humphries, S., Knapton, M., Perk, J., Priori, S. G., Pyorala, K., Reiner, Z., Ruilope, L., Sans-Menendez, S., Scholte op Reimer, W., Weissberg, P., Wood, D., Yarnell, J., Zamorano, J. L., Other experts who contributed to parts of the guid, , Walma, E., Fitzgerald, T., Cooney, M. T., Dudina, A., European Society of Cardiology (ESC) Committee for, , Vahanian, A., Camm, J., De Caterina, R., Dean, V., Dickstein, K., Funck-Brentano, C., Filippatos, G., Hellemans, I., Kristensen, S. D., McGregor, K., Sechtem, U., Silber, S., Tendera, M., Widimsky, P., Zamorano, J. L., Document reviewers:, , Hellemans, I., Altiner, A., Bonora, E., Durrington, P. N., Fagard, R., Giampaoli, S., Hemingway, H., Hakansson, J., Kjeldsen, S. E., Larsen, M. L., Mancia, G., Manolis, A. J., Orth-Gomer, K., Pedersen, T., Rayner, M., Ryden, L., Sammut, M., Schneiderman, N., Stalenhoef, A. F., Tokgozoglu, L., Wiklund, O., Zampelas, A. (2007). European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by representatives of nine societies and by invited experts). Eur Heart J 28: 2375-2414 [Full Text]  
• Gnavi, R., Migliardi, A., Demaria, M., Petrelli, A., Caprioglio, A., Costa, G. (2007). Statins prescribing for the secondary prevention of ischaemic heart disease in Torino, Italy. A case of ageism and social inequalities. Eur J Public Health 17: 492-496 [Abstract] [Full Text]  
• Marschner, I. C., Simes, R. J., Keech, A. (2007). Biases in the Identification of Risk Factor Thresholds and J-Curves. Am J Epidemiol 166: 824-831 [Abstract] [Full Text]  
• Hippisley-Cox, J., Parker, C., Coupland, C., Vinogradova, Y. (2007). Inequalities in the primary care of patients with coronary heart disease and serious mental health problems: a cross-sectional study. Heart 93: 1256-1262 [Abstract] [Full Text]  
• Cahoon, W. D Jr, Crouch, M. A (2007). Preprocedural Statin Therapy in Percutaneous Coronary Intervention. The Annals of Pharmacotherapy 41: 1687-1693 [Abstract] [Full Text]  
• Colivicchi, F., Bassi, A., Santini, M., Caltagirone, C. (2007). Discontinuation of Statin Therapy and Clinical Outcome After Ischemic Stroke. Stroke 38: 2652-2657 [Abstract] [Full Text]  
• Lipson, A. H., Fallis, W. M., Wang, X., Yi, Y. (2007). Are patients with hyperlipidemia undertreated?: Study of patients admitted to hospital with coronary events. cfp 53: 1502-1507 [Abstract] [Full Text]  
• Anderson, J. L., Adams, C. D., Antman, E. M., Bridges, C. R., Califf, R. M., Casey, D. E. Jr, Chavey, W. E. II, Fesmire, F. M., Hochman, J. S., Levin, T. N., Lincoff, A. M., Peterson, E. D., Theroux, P., Wenger, N. K., Wright, R. S., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Antman, E. M., Halperin, J. L., Hunt, S. A., Krumholz, H. M., Kushner, F. G., Lytle, B. W., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B. (2007). ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) Developed in Collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. J Am Coll Cardiol 50: e1-e157 [Full Text]  
• Anderson, J. L., Adams, C. D., Antman, E. M., Bridges, C. R., Califf, R. M., Casey, D. E. Jr, Chavey, W. E. II, Fesmire, F. M., Hochman, J. S., Levin, T. N., Lincoff, A. M., Peterson, E. D., Theroux, P., Wenger, N. K., Wright, R. S., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Antman, E. M., Halperin, J. L., Hunt, S. A., Krumholz, H. M., Kushner, F. G., Lytle, B. W., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B. (2007). ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction) Developed in Collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. J Am Coll Cardiol 50: 652-726 [Full Text]  
• Chiodini, B. D., Franzosi, M. G., Barlera, S., Signorini, S., Lewis, C. M., D'Orazio, A., Mocarelli, P., Nicolis, E., Marchioli, R., Tognoni, G., on behalf of GISSI Investigators, , SIBioC-GISSI Prevenzione Group, (2007). Apolipoprotein E polymorphisms influence effect of pravastatin on survival after myocardial infarction in a Mediterranean population: the GISSI-Prevenzione study. Eur Heart J 28: 1977-1983 [Abstract] [Full Text]  
• Alsheikh-Ali, A. A., Maddukuri, P. V., Han, H., Karas, R. H. (2007). Effect of the Magnitude of Lipid Lowering on Risk of Elevated Liver Enzymes, Rhabdomyolysis, and Cancer: Insights From Large Randomized Statin Trials. J Am Coll Cardiol 50: 409-418 [Abstract] [Full Text]  
• McWilliams, J. M., Meara, E., Zaslavsky, A. M., Ayanian, J. Z. (2007). Use of Health Services by Previously Uninsured Medicare Beneficiaries. NEJM 357: 143-153 [Abstract] [Full Text]  
• Simpson, C. S. MD (2007). Implantable cardioverter defibrillators work so why aren't we using them?. CMAJ 177: 49-51 [Full Text]  
• Wenger, N. K., Lewis, S. J., Herrington, D. M., Bittner, V., Welty, F. K., for the Treating to New Targets Study Steering Com, (2007). Outcomes of Using High- or Low-Dose Atorvastatin in Patients 65 Years of Age or Older with Stable Coronary Heart Disease. ANN INTERN MED 147: 1-9 [Abstract] [Full Text]  
• Schmidt, G. A., Hoehns, J. D., Purcell, J. L., Friedman, R. L., Elhawi, Y. (2007). Severe Rhabdomyolysis and Acute Renal Failure Secondary to Concomitant Use of Simvastatin, Amiodarone, and Atazanavir. J Am Board Fam Med 20: 411-416 [Abstract] [Full Text]  
• Kitayama, J., Faraci, F. M., Lentz, S. R., Heistad, D. D. (2007). Cerebral Vascular Dysfunction During Hypercholesterolemia. Stroke 38: 2136-2141 [Abstract] [Full Text]  
• Kostapanos, M.S., Liberopoulos, E.N., Goudevenos, J.A., Mikhailidis, D.P., Elisaf, M.S. (2007). Do statins have an antiarrhythmic activity?. Cardiovasc Res 75: 10-20 [Abstract] [Full Text]  
• Nanayakkara, P. W. B., van Guldener, C., ter Wee, P. M., Scheffer, P. G., van Ittersum, F. J., Twisk, J. W., Teerlink, T., van Dorp, W., Stehouwer, C. D. A. (2007). Effect of a Treatment Strategy Consisting of Pravastatin, Vitamin E, and Homocysteine Lowering on Carotid Intima-Media Thickness, Endothelial Function, and Renal Function in Patients With Mild to Moderate Chronic Kidney Disease: Results From the Anti-Oxidant Therapy in Chronic Renal Insufficiency (ATIC) Study. Arch Intern Med 167: 1262-1270 [Abstract] [Full Text]  
• Montalescot, G., Dallongeville, J., Van Belle, E., Rouanet, S., Baulac, C., Degrandsart, A., Vicaut, E., for the OPERA Investigators, (2007). STEMI and NSTEMI: are they so different? 1 year outcomes in acute myocardial infarction as defined by the ESC/ACC definition (the OPERA registry). Eur Heart J 28: 1409-1417 [Abstract] [Full Text]  
• Authors/Task Force Members, , Ryden, L., Standl, E., Bartnik, M., Berghe, G. V. d., Betteridge, J., de Boer, M.-J., Cosentino, F., Jonsson, B., Laakso, M., Malmberg, K., Priori, S., Ostergren, J., Tuomilehto, J., Thrainsdottir, I., Other Contributors, , Vanhorebeek, I., Stramba-Badiale, M., Lindgren, P., Qiao, Q., ESC Committee for Practice Guidelines (CPG), , Priori, S. G., Blanc, J.-J., Budaj, A., Camm, J., Dean, V., Deckers, J., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J., Zamorano, J. L., Document Reviewers, , Deckers, J. W., Bertrand, M., Charbonnel, B., Erdmann, E., Ferrannini, E., Flyvbjerg, A., Gohlke, H., Juanatey, J. R. G., Graham, I., Monteiro, P. F., Parhofer, K., Pyorala, K., Raz, I., Schernthaner, G., Volpe, M., Wood, D. (2007). Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: full text: The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). Eur Heart J Suppl 9: C3-C74 [Full Text]  
• Haramaki, N., Ikeda, H., Takenaka, K., Katoh, A., Sugano, R., Yamagishi, S.-i., Matsuoka, H., Imaizumi, T. (2007). Fluvastatin Alters Platelet Aggregability in Patients With Hypercholesterolemia: Possible Improvement of Intraplatelet Redox Imbalance via HMG-CoA Reductase. Arterioscler. Thromb. Vasc. Bio. 27: 1471-1477 [Abstract] [Full Text]  
• Tuzcu, E. M., Nicholls, S. J. (2007). Statins: Targeting Inflammation by Lowering Low-Density Lipoprotein?. J Am Coll Cardiol 49: 2010-2012 [Full Text]  
• Kinlay, S. (2007). Low-Density Lipoprotein-Dependent and -Independent Effects of Cholesterol-Lowering Therapies on C-Reactive Protein: A Meta-Analysis. J Am Coll Cardiol 49: 2003-2009 [Abstract] [Full Text]  
• Alexander, K. P., Newby, L. K., Armstrong, P. W., Cannon, C. P., Gibler, W. B., Rich, M. W., Van de Werf, F., White, H. D., Weaver, W. D., Naylor, M. D., Gore, J. M., Krumholz, H. M., Ohman, E. M. (2007). Acute Coronary Care in the Elderly, Part II: ST-Segment-Elevation Myocardial Infarction: A Scientific Statement for Healthcare Professionals From the American Heart Association Council on Clinical Cardiology: In Collaboration With the Society of Geriatric Cardiology. Circulation 115: 2570-2589 [Abstract] [Full Text]  
• Yanai, H., Yoshida, H., Tomono, Y., Tada, N. (2007). Atherosclerosis imaging in statin intervention trials. QJM 100: 253-262 [Full Text]  
• Sassano, A., Katsoulidis, E., Antico, G., Altman, J. K., Redig, A. J., Minucci, S., Tallman, M. S., Platanias, L. C. (2007). Suppressive Effects of Statins on Acute Promyelocytic Leukemia Cells. Cancer Res. 67: 4524-4532 [Abstract] [Full Text]  
• Khurana, V., Bejjanki, H. R., Caldito, G., Owens, M. W. (2007). Statins Reduce the Risk of Lung Cancer in Humans: A Large Case-Control Study of US Veterans. Chest 131: 1282-1288 [Abstract] [Full Text]  
• Schneeweiss, S., Patrick, A. R., Maclure, M., Dormuth, C. R., Glynn, R. J. (2007). Adherence to Statin Therapy Under Drug Cost Sharing in Patients With and Without Acute Myocardial Infarction: A Population-Based Natural Experiment. Circulation 115: 2128-2135 [Abstract] [Full Text]  
• Brookhart, M. A., Patrick, A. R., Schneeweiss, S., Avorn, J., Dormuth, C., Shrank, W., van Wijk, B. L. G., Cadarette, S. M., Canning, C. F., Solomon, D. H. (2007). Physician Follow-up and Provider Continuity Are Associated With Long-term Medication Adherence: A Study of the Dynamics of Statin Use. Arch Intern Med 167: 847-852 [Abstract] [Full Text]  
• Fagan, S. C., Elewa, H. F., Rychly, D. J. (2007). Statin Therapy for Secondary Stroke Prevention: Evidence Catches Up to Practice. Journal of Pharmacy Practice 20: 117-122 [Abstract]  
• Patel, T. N., Shishehbor, M. H., Bhatt, D. L. (2007). A review of high-dose statin therapy: targeting cholesterol and inflammation in atherosclerosis. Eur Heart J 28: 664-672 [Abstract] [Full Text]  
• Yamamoto, E., Yamashita, T., Tanaka, T., Kataoka, K., Tokutomi, Y., Lai, Z.-F., Dong, Y.-F., Matsuba, S., Ogawa, H., Kim-Mitsuyama, S. (2007). Pravastatin Enhances Beneficial Effects of Olmesartan on Vascular Injury of Salt-Sensitive Hypertensive Rats, via Pleiotropic Effects. Arterioscler. Thromb. Vasc. Bio. 27: 556-563 [Abstract] [Full Text]  
• Nicholls, S. J., Tuzcu, E. M., Sipahi, I., Grasso, A. W., Schoenhagen, P., Hu, T., Wolski, K., Crowe, T., Desai, M. Y., Hazen, S. L., Kapadia, S. R., Nissen, S. E. (2007). Statins, High-Density Lipoprotein Cholesterol, and Regression of Coronary Atherosclerosis. JAMA 297: 499-508 [Abstract] [Full Text]  
• Houslay, E. S, Sarma, J., Uren, N. G (2007). The effect of intensive lipid lowering on coronary atheroma and clinical outcome. Heart 93: 149-151 [Abstract] [Full Text]  
• Robinson, J. G., Bakris, G., Torner, J., Stone, N. J., Wallace, R. (2007). Is it Time for a Cardiovascular Primary Prevention Trial in the Elderly?. Stroke 38: 441-450 [Abstract] [Full Text]