FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 339:127-128 July 9, 1998 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Moliterno, A. R. PubMed Citation

To the Editor: In the February 26 issue, Moliterno et al.¹ report on the reduced expression of the thrombopoietin receptor Mpl as a new characteristic of polycythemia vera and idiopathic myelofibrosis. On the basis of this reduced expression, they suggest a subsequent failure of activation of the Janus kinase signaling system due to an unknown upstream defect, with subsequent loss of phosphorylation of JAK2 and STAT5. After stimulation of platelets from normal subjects with thrombopoietin or thrombin, the authors observed tyrosine phosphorylation of proteins of approximately 125, 95, and 85 kd. Interestingly, this phosphorylation pattern could be observed in the . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Teofili, L., Pierconti, F., Di Febo, A., Maggiano, N., Vianelli, N., Ascani, S., Rossi, E., Pileri, S., Leone, G., Larocca, L. M., De Stefano, V. (2002). The expression pattern of c-mpl in megakaryocytes correlates with thrombotic risk in essential thrombocythemia. Blood 100: 714-717 [Abstract] [Full Text]