The diagnosis and treatment of pulmonary embolism demand aninterdisciplinary approach, combining medical, surgical, andradiologic specialties. Despite substantial advances, mortalityand recurrence rates remain high. The present article addressesthrombotic venous thromboembolism, even though the term "pulmonaryembolism" encompasses embolism from many sources, includingair, bone marrow, arthroplasty cement, amniotic fluid, tumor,talc, and sepsis.
Epidemiology and Pathophysiology
Pulmonary embolism ranges from incidental, clinically unimportantthromboembolism to massive embolism with sudden death. Hypercoagulabilityleads to the formation of thrombus in the leg veins, with proximalextension as the clot propagates. As thrombi form in the deepveins of the legs, pelvis, or . . . [Full Text of this Article]
Incidence, Mortality, and Recurrence
Right Ventricular Function
Risk Factors
Thrombophilia
Diagnosis
Therapy
Prevention
Conclusions
Source Information
From the Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston.
Address reprint requests to Dr. Goldhaber at the Cardiovascular Division, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115.
References
Related Letters:
Pulmonary Embolism
Schrijvers D., Van den Brande J., Vermorken J. B., Corbanese U., Possamai C., Blatt P. M., Marlar R. A., Joist J. H., Fink L. M., Goldhaber S. Z.
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N Engl J Med 1998;
339:1555-1557, Nov 19, 1998.
Correspondence
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