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Correction to Pastuszak et al., N Engl J Med 338(26):1881-1885 June 25, 1998.

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Volume 339:1553-1554 November 19, 1998 Number 21
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Use of Misoprostol during Pregnancy and Möbius' Syndrome in Infants

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 by Pastuszak, A. L.
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 by Pastuszak, A. L.
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To the Editor: In their paper describing the association between the reported use of misoprostol in unsuccessful attempts to terminate pregnancy and Möbius' syndrome in infants, Pastuszak et al. (June 25 issue)1 conclude that the "administration of misoprostol during pregnancy should be strongly discouraged, given the drug's low efficacy and its likelihood of causing fetal malformations." We disagree. The suitability of administering misoprostol during pregnancy depends entirely on the intended effect. If the desired outcome is the medical termination of unwanted pregnancy, cervical priming before vacuum aspiration, or prevention of postpartum hemorrhage, concern about potential fetal malformation is misplaced, and . . . [Full Text of this Article]

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