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Correspondence
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Volume 339:1555-1557 November 19, 1998 Number 21
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Pulmonary Embolism

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 by Decousus, H.
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 by Goldhaber, S. Z.
To the Editor: In his article on pulmonary embolism, Dr. Goldhaber (July 9 issue)1 states that unfractionated heparin "constitutes the cornerstone" of treatment, and he mentions fractionated, or low-molecular-weight, heparin only in the discussion of prevention. Nevertheless, there have been two randomized trials in patients with pulmonary embolism that show that low-molecular-weight heparin is as effective as unfractionated heparin in regard to the incidence of recurrence, major bleeding complications, and death. In one study, which involved 612 patients with symptomatic pulmonary embolism who did not require thrombolytic therapy or embolectomy, subcutaneous low-molecular-weight heparin (tinzaparin) given once daily in a fixed . . . [Full Text of this Article]

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