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Case Records of the Massachusetts General Hospital
Weekly Clinicopathological Exercises
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Volume 339:2005-2012 December 31, 1998 Number 27
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Case 40-1998— A 49-Year-Old Woman with Thrombotic Thrombocytopenic Purpura and Severe Dyspnea during Plasmapheresis and Transfusion
Mark A. Popovsky, and Susan L. Saidman

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Presentation of Case

A 49-year-old right-handed woman was admitted to the hospital because of a hemorrhagic stroke and mutism.

The patient had been well until two weeks earlier, when she began to have menorrhagia and orthostatic weakness. One day before admission, she entered another hospital, where she was found to have uterine leiomyomas. Laboratory studies were performed (Table 1 and Table 2). Two units of packed red cells were transfused, and dilation with curettage was performed. On the next day, she felt better until midday, when she suddenly had a severe headache, followed by an inability to speak, although she could . . . [Full Text of this Article]

Differential Diagnosis

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Dr. Mark A. Popovsky's Diagnosis

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