For many years, the functional sequelae of chronic coronaryartery disease were considered irreversible and amenable onlyto palliative therapy. For example, a finding of asynergy (theabsence of contraction) on the left ventriculogram was thoughtto indicate the presence of infarcted myocardium or scarring.It is now clear, however, that chronic left ventricular dysfunction(i.e., reduced contraction or even asynergy) in patients withcoronary artery disease is not necessarily irreversible.
This new concept is based on two earlier observations. The firstwas that myocardial dysfunction that was present before theperformance of coronary-artery bypass grafting was often reversedafter . . . [Full Text of this Article]
Clinical Aspects of Hibernating Myocardium
Patterns of Left Ventricular Dysfunction
Incidence
Identification of Patients with Hibernating Myocardium
Effect of Treatment
Histopathological Features
Pathophysiologic Mechanisms
Conclusions
Source Information
From the Cardiovascular Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium (W.W.); the Cardiovascular and Pulmonary Research Institute, Allegheny University of the Health Sciences, Pittsburgh (S.F.V.); and the Medical Research Council Cyclotron Unit, Imperial College School of Medicine, Hammersmith Hospital, London (P.G.C.).
Address reprint requests to Dr. Vatner at the Cardiovascular and Pulmonary Research Institute, Allegheny University of the Health Sciences, 320 E. North Ave., Pittsburgh, PA 15212.
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