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Previous Volume 339:307-311 July 30, 1998 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Editorial by Cohen, O. J. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Combination treatments with agents that inhibit protease and reverse transcriptase of human immunodeficiency virus type 1 (HIV-1) decrease mortality and slow disease progression.¹ The development of resistance to these drugs, however, limits the benefit of such treatments.^2,3 There have been reports of the transmission of HIV-1 variants that are resistant to nucleoside and non-nucleoside inhibitors of reverse transcriptase.^4,5,6,7,8,9 The transmission of HIV-1 variants that are resistant to protease inhibitors could represent an important emerging clinical and public health problem. We report a case of transmission of an HIV-1 variant with multiple mutations that conferred resistance to both protease inhibitors and . . . [Full Text of this Article]

Case Report

Methods

Results

Discussion

Source Information

From the AIDS Program, San Francisco General Hospital and University of California, San Francisco, San Francisco (F.M.H., R.M.G., J.O.K.); the Gladstone Institute of Immunology and Virology, San Francisco (R.M.G., N.I.B., L.D.); ViroLogic, South San Francisco, Calif. (C.J.P., H.T., N.S.H.); the Centers for Disease Control and Prevention, Atlanta (B.D., B.B.); and the Center for AIDS Prevention Studies, University of California, San Francisco, San Francisco (M.A.C.).

Address reprint requests to Dr. Hecht at the UCSF AIDS Program, 995 Potrero Ave., Ward 84, San Francisco, CA 94110.

References

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